Prevalence of Abnormal Postures in Parkinson's Disease

NCT ID: NCT03573232

Last Updated: 2018-07-17

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 794 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-03-07
• Study Completion Date: 2018-10-07

Brief Summary

Postural abnormalities represent disabling and painful complications in patients with Parkinson's disease (PD). The stooped posture is a typical feature of PD but with advancing of disease more severe body abnormalities can affect people with PD. These deformities include Pisa syndrome, camptocormia, antecollis, scoliosis and striatal deformities related to hand (striatal hand) and/or toes (striatal toes).

Detailed Description

Postural abnormalities represent disabling and painful complications in patients with Parkinson's disease (PD). The first postural trunk deviation in PD was first described by James Parkinson himself and recognized as stooped simian appearance, with flexion of the hips and knees, and rounding of the shoulders. Although the stooped posture is a typical feature, more severe spinal misalignment (and deformities) can affect people with PD. These postural deformities include Pisa syndrome (PS), camptocormia (CP), antecollis (AC), scoliosis (S) and striatal deformities related to hand (striatal hand) and/or toes (striatal toes). The prevalence of these postural deformities is variable because several diagnostic criteria have been used to characterize each deformity. Recently, a consensus of diagnostic criteria has been reached in literature permitting us to better mapping the presence of these deformities in people with PD.

Conditions

Parkinson Disease

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

1. Participants will be considered enrolled after signing the consent form;

2. Diagnosis of Parkinson's disease;

Exclusion Criteria

1. Concomitant neurologic diseases known to negatively affect posture;

2. A history of major spinal surgery or muscle and/or skeletal diseases;

3. Treatment with drugs potentially able to induce abnormal postures;

4. Clinical features consistent with a diagnosis of atypical parkinsonism;

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Universita di Verona

OTHER

Sponsor Role: lead

Responsible Party

Michele Tinazzi, MD, PhD

M.D., Ph.D. Full Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Michele Tinazzi, MD, PhD, Professor

Role: PRINCIPAL_INVESTIGATOR

Universita di Verona

Nicola Smania, MD, Professor

Role: STUDY_CHAIR

Universita di Verona

Marialuisa Gandolfi, MD, PhD

Role: STUDY_CHAIR

Universita di Verona

Christian Geroin, PhD

Role: STUDY_CHAIR

Universita di Verona

Locations

Department of Experimental and Clinical Medicine - University "Politecnica delle Marche" Ancona -Italy. Neurorehabilitation Clinic - Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona.

Ancona, , Italy

Site Status: RECRUITING

Department of Neuroscience, Imaging and Clinical Sciences, University G.d'Annunzio of Chieti-Pescara

Pescara, , Italy

Site Status: RECRUITING

Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Pisa, , Italy

Site Status: RECRUITING

IRCCS San Raffaele CTC Centro Parkinson Via della Pisana 235, 00163 Roma

Roma, , Italy

Site Status: RECRUITING

Dipartimento di Neuroscienze A.O. Città della Salute e della Scienza di Torino

Torino, , Italy

Site Status: RECRUITING

Clinica Neurologica, Dipartimento di Scienze Neurologiche, Chirurgiche e della Salute, Azienda Ospedaliera Universitaria integrata, Universita' di Trieste

Trieste, , Italy

Site Status: RECRUITING

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona

Verona, , Italy

Site Status: RECRUITING

Countries

Italy

Central Contacts

Michele Tinazzi, MD, PhD, Professor

Role: CONTACT

michele.tinazzi@univr.it

0458124287

Christian Geroin, PhD

Role: CONTACT

christian.geroin@univr.it

Facility Contacts

Marianna Capecci, MD, PhD

Role: primary

m.capecci@univpm.it

Laura Bonanni, MD, PhD

Role: primary

l.bonanni@unich.it

Roberto Ceravolo, MD, Professor

Role: primary

r.ceravolo@med.unipi.it

Fabrizio Stocchi, MD

Role: primary

fabrizio.stocchi@fastwebnet.it

Maurizio Zibetti, MD

Role: primary

maurizio.zibetti@gmail.com

Paolo Manganotti, MD, PhD

Role: primary

pmanganotti@units.it

Michele Tinazzi, MD, PhD, Professor

Role: primary

michele.tinazzi@univr.it

References

Doherty KM, van de Warrenburg BP, Peralta MC, Silveira-Moriyama L, Azulay JP, Gershanik OS, Bloem BR. Postural deformities in Parkinson's disease. Lancet Neurol. 2011 Jun;10(6):538-49. doi: 10.1016/S1474-4422(11)70067-9. Epub 2011 Apr 22.

Reference Type: BACKGROUND

PMID: 21514890 (View on PubMed)

Tinazzi M, Geroin C, Gandolfi M, Smania N, Tamburin S, Morgante F, Fasano A. Pisa syndrome in Parkinson's disease: An integrated approach from pathophysiology to management. Mov Disord. 2016 Dec;31(12):1785-1795. doi: 10.1002/mds.26829. Epub 2016 Oct 25.

Reference Type: BACKGROUND

PMID: 27779784 (View on PubMed)

Srivanitchapoom P, Hallett M. Camptocormia in Parkinson's disease: definition, epidemiology, pathogenesis and treatment modalities. J Neurol Neurosurg Psychiatry. 2016 Jan;87(1):75-85. doi: 10.1136/jnnp-2014-310049. Epub 2015 Apr 20.

Reference Type: BACKGROUND

PMID: 25896683 (View on PubMed)

Pandey S, Garg H. Postural & striatal deformities in Parkinson;s disease: Are these rare? Indian J Med Res. 2016 Jan;143(1):11-7. doi: 10.4103/0971-5916.178577.

Reference Type: BACKGROUND

PMID: 26997007 (View on PubMed)

Other Identifiers

Università di Verona

Identifier Type: -

Identifier Source: org_study_id