Dysport in Hallux Abducto Valgus (HAV) Phase IIa

NCT ID: NCT03569098

Last Updated: 2021-07-02

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

186 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-06-19

Study Completion Date

2020-05-22

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to investigate the efficacy and safety of treatment with multiple doses of Dysport in adults suffering from clinically significant pain associated with HAV who have not undergone surgery for their condition.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hallux Abducto Valgus

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Dysport Dose 1

Intramuscular injection of Dysport on day 1 of double-blind period, followed by up to 2 open-label injections during open-label cycles, during approximately 36 weeks.

Group Type EXPERIMENTAL

Botulinum toxin type A

Intervention Type BIOLOGICAL

Investigators will inject the reconstituted solution into foot muscles.

Dysport Dose 2

Intramuscular injection of Dysport on day 1 of double-blind period, followed by up to 2 open-label injections during open-label cycles, during approximately 36 weeks.

Group Type EXPERIMENTAL

Botulinum toxin type A

Intervention Type BIOLOGICAL

Investigators will inject the reconstituted solution into foot muscles.

Placebo

Intramuscular injection of Placebo on day 1 of cycle 1 (double-blind period)

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Investigators will inject the reconstituted solution into foot muscles.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Botulinum toxin type A

Investigators will inject the reconstituted solution into foot muscles.

Intervention Type BIOLOGICAL

Placebo

Investigators will inject the reconstituted solution into foot muscles.

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

AbobotulinumtoxinA (Dysport®) Clostridium botulinum toxin type A haemagglutinin complex (BTX-A-HAC)

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Clinical diagnosis of HAV
* Painful HAV in the study foot at Baseline

Exclusion Criteria

* Flat or square metatarsal head, metatarsus primus elevates, or severe cavus/planus in the study foot
* Other podiatric or orthopedic condition which would interfere with the evaluation of pain and/or function
* Medical history or clinical evidence of any vascular disease and/or diabetic condition
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Ipsen

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Ipsen Medical Director

Role: STUDY_DIRECTOR

Ipsen

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

NEA Baptist Clinic

Jonesboro, Arkansas, United States

Site Status

Applied Research Center of Arkansas, Inc

Little Rock, Arkansas, United States

Site Status

Center for Clinical Research Inc.

Castro Valley, California, United States

Site Status

Limb Preservation Platform, Inc.

Fresno, California, United States

Site Status

Southwestern Academic Limb Salvage Alliance

Los Angeles, California, United States

Site Status

Foot and Ankle Clinic

Los Angeles, California, United States

Site Status

University Foot and Ankle Institute

Santa Monica, California, United States

Site Status

Center for Spine and Orthopedics

Thornton, Colorado, United States

Site Status

LCC Medical Research Institute

Miami, Florida, United States

Site Status

Conquest Research

Orlando, Florida, United States

Site Status

Doctors Research Network

South Miami, Florida, United States

Site Status

Clinical Research

West Palm Beach, Florida, United States

Site Status

Podiatry 1st

Belleville, Illinois, United States

Site Status

Weil Foot & Ankle Institute

Des Plaines, Illinois, United States

Site Status

Rosalind Franklin Clinic

North Chicago, Illinois, United States

Site Status

Foot and Ankle Center of Illinois

Springfield, Illinois, United States

Site Status

The Chesapeake Research Group

Pasadena, Maryland, United States

Site Status

Dr. Allen M. Jacobs and Associates

St Louis, Missouri, United States

Site Status

Ankle and Foot Care Centers

Youngstown, Ohio, United States

Site Status

Medical Research International

Oklahoma City, Oklahoma, United States

Site Status

Foot and Ankle Center

Bryn Mawr, Pennsylvania, United States

Site Status

Harrisburg Foot and Ankle Center, INC

Harrisburg, Pennsylvania, United States

Site Status

Futuro Clinical Trials, LLC

McAllen, Texas, United States

Site Status

Bio X Cell Research

San Antonio, Texas, United States

Site Status

Texas Gulf Coast Medical Group

Webster, Texas, United States

Site Status

Summit Foot & Ankle

Salt Lake City, Utah, United States

Site Status

Harrisonburg Foot and Ankle Clinic

Harrisonburg, Virginia, United States

Site Status

1Foot 2Foot Centre for Foot and Ankle Care, PC

Suffolk, Virginia, United States

Site Status

Martinsville Research Institute, Inc.

Salem, West Virginia, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

D-FR-52120-237

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Dysport Dose-Ranging Treatment of Platysmal Bands
NCT04886167 UNKNOWN PHASE1/PHASE2
Dysport in Vulvodynia Phase II Study
NCT03598777 TERMINATED PHASE2
Dysport® Adult Upper Limb Spasticity
NCT01313299 COMPLETED PHASE3