18F-PD-L1 PET/CT in Nivolumab Treated Patients With NSCLC

NCT ID: NCT03564197

Last Updated: 2023-10-18

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 80 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-10-25
• Study Completion Date: 2024-12-30

Brief Summary

A multicenter single arm biomarker exploration and validation study. Eighty patients with NSCLC that are eligible for first line chemo-immunotherapy, first line nivolumab/ipilimumab or 2nd line and beyond PD-(L)1 immunotherapy monotherapy according to EMA label and national guidelines will be enrolled in this trial. All subjects will undergo a whole body 18F-PD-L1 PET/CT scan before start of nivolumab containing treatment. Patients will continue treatment until disease progression, withdrawal of patient consent or unacceptable toxicity.

Detailed Description

18F-PD-L1 PET/CT scan to predict durable reponse to nivolumab containing treatment in patients with NSCLC

Conditions

NSCLC Stage IV

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Nivolumab

nivolumab containing treatment according to label

Group Type: OTHER

18F-PD-L1

Intervention Type: OTHER

18F-PD-L1 PET/CT scan

Interventions

18F-PD-L1

18F-PD-L1 PET/CT scan

Intervention Type: OTHER

Other Intervention Names

tracer

Eligibility Criteria

Inclusion Criteria

1. Have a histologically or cytologically confirmed diagnosis of stage IV, EGFR WT and EML4-ALK fusion negative NSCLC. Mutational testing is not necessary in patients with squamous NSCLC.

2. Eligible for first line chemo-immunotherapy, first line nivolumab + ipilimumab or 2nd line and beyond PD-(L)1 immunotherapy monotherapy.

3. Be willing and able to provide written informed consent for the trial.

4. Be >= 18 years of age on day of signing informed consent.

5. Have measurable disease based on RECIST 1.1.

6. Must provide tissue from a histological biopsy of a tumor lesion that is not radiated prior to biopsy and obtained after the last line of systemic therapy, to determine the actual PD-L1 status.

7. Have a performance status of 0-1 on the ECOG Performance Scale.

8. Demonstrate adequate hematologic and organ function, defined by the following laboratory results. All screening laboratory tests should be performed within 30 days prior to day 1 (PET imaging):

• Absolute neutrophil count (ANC) ≥ 1500 cells/µL
• WBC count ≥ 2000 cells/µL
• Platelet count ≥ 100.000/µL
• Hemoglobin ≥ 5.6 mmol/L
• AST and ALT ≤ 3 x ULN (≤ 5 x ULN if liver metastases are present)
• Serum bilirubin ≤ 1.5 x ULN (except subjects with known Gilbert disease, who can have total bilirubin < 3.0 mg/dL)
• Serum Creatinine ≤ 1.5 x ULN OR measured of calculated creatinine clearance (GFR can also be used in place of creatinine or CrCl) ≥ 40 mL/min for subject with creatinine levels > 1.5 x ULN.

Exclusion Criteria

1. Subjects with a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days prior to day 1 (PET imaging). Inhaled or topical steroids, and adrenal replacement steroid >10 mg daily prednisone equivalent, are permitted in the absence of active autoimmune disease.

2. Has a known additional malignancy that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or in situ cervical cancer that has undergone potentially curative therapy.

3. Has symptomatic central nervous system (CNS) metastases and/or carcinomatous meningitis.

• Note: Subjects with asymptomatic CNS metastases are allowed to enter the study.
• Note: Subjects with previously treated brain metastases may participate provided they are clinically stable and not using steroids with > 10 mg daily prednisone equivalent for at least 7 days prior to trial treatment.

4. Has an active autoimmune disease requiring systemic steroid treatment within the past 3 months or a documented history of clinically severe autoimmune disease, or a syndrome that requires systemic steroids.

5. Has evidence of interstitial lung disease or active, non-infectious pneumonitis.

6. Has an active infection requiring systemic therapy.

7. Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator.

8. Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.

9. Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the pre-screening or screening visit through 23 weeks after the last dose of trial treatment.

10. Has received prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways.

11. Has a known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies).

12. Has known active Hepatitis B or C.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Bristol-Myers Squibb

INDUSTRY

Sponsor Role: collaborator

The Netherlands Cancer Institute

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Joop de Langen, MD

Role: PRINCIPAL_INVESTIGATOR

The Netherlands Cancer Institute-Antoni van Leeuwenhoek

Egbert Smit, MD

Role: PRINCIPAL_INVESTIGATOR

The Netherlands Cancer Institute-Antoni van Leeuwenhoek

Locations

Jeroen Bosch Ziekenhuis

's-Hertogenbosch, , Netherlands

Site Status: RECRUITING

MeanderMC

Amersfoort, , Netherlands

Site Status: RECRUITING

VUmc

Amsterdam, , Netherlands

Site Status: NOT_YET_RECRUITING

Antoni van Leeuwenhoek

Amsterdam, , Netherlands

Site Status: RECRUITING

Deventer Ziekenhuis

Deventer, , Netherlands

Site Status: RECRUITING

LUMC

Leiden, , Netherlands

Site Status: RECRUITING

Medisch Centrum Haaglanden

The Hague, , Netherlands

Site Status: RECRUITING

Antonius Ziekenhuis

Utrecht, , Netherlands

Site Status: RECRUITING

Countries

Netherlands

Central Contacts

Joop de Langen, MD

Role: CONTACT

j.d.langen@nki.nl

+3120512 ext. 9111

Marianne Mahn, MSc

Role: CONTACT

m.mahn@nki.nl

+3120512 ext. 2974

Facility Contacts

Bonne Biesma, MD, PhD

Role: primary

b.biesma@jbz.nl

Judith Herder, MD, PhD

Role: primary

Idris Bahce, MD

Role: primary

i.bahce@vumc.nl

+3120444 ext. 4782

Joop de Langen, MD, PhD

Role: primary

S. Samii, MD

Role: primary

s.samii@dz.nl

Jasper Smit, MD

Role: primary

K Maas, MD

Role: primary

k.maas@mchaaglanden.nl

Lisanne Kastelijn, MD, PhD

Role: primary

Other Identifiers

CA209-9XC

Identifier Type: OTHER

Identifier Source: secondary_id

M17FNN

Identifier Type: -

Identifier Source: org_study_id