A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer

NCT ID: NCT03561220

Last Updated: 2025-09-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

3000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-07-05

Study Completion Date

2026-04-01

Brief Summary

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This study is a large, prospective, pragmatic, controlled comparison of patient-centric outcomes \[quality of life (QOL), toxicity, and disease control\] between parallel cohorts of men with prostate cancer treated simultaneously at proton therapy facilities and at geographically similar conventional (photon-based) radiation facilities using intensity-modulated radiation therapy (IMRT) techniques.

Detailed Description

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This study is a large, prospective, pragmatic, controlled comparison of patient-centric outcomes \[quality of life (QOL), toxicity, and disease control\] between parallel cohorts of men with prostate cancer treated simultaneously at proton therapy facilities and at geographically similar conventional (photon-based) radiation facilities using intensity-modulated radiation therapy (IMRT) techniques. This study includes a pre-specified randomized comparison of standard fractionation and moderate hypofractionation dose schemes within the proton therapy cohort. In addition, subgroup analyses will include a comparison of outcomes by race (Black vs. White), comorbidity score (0 vs. 1+), age (\<65 vs. ≥65), fractionation schedule (standard, moderate, ultra-hypofractionation), and prostate cancer aggressiveness (very low and low, intermediate, and high risk) for all objectives.

All interventions will be standard of care (SOC) radiation strategies using either IMRT or proton therapy. All patient-reported QOL, patient-scored and patient-reported toxicity, and disease control assessments will be SOC. Participants will also complete pretreatment surveys regarding demographic data, personal treatment goals, factors affecting treatment decision-making, and sources of information used in treatment selection.

Conditions

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Prostate Cancer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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IMRT (Photon)

As this trial is pragmatic, all treatment will be standard of care.

Group Type ACTIVE_COMPARATOR

Standard of Care IMRT (Photon)

Intervention Type RADIATION

As this trial is pragmatic, all treatment will be standard of care.

Proton Therapy Standard of Care

As this trial is pragmatic, all treatment will be standard of care.

Group Type ACTIVE_COMPARATOR

Standard of Care Proton Therapy

Intervention Type RADIATION

As this trial is pragmatic, all treatment will be standard of care.

Standard Proton Therapy

78.0 Gy (RBE) in 39 fractions. This is Arm 1 of the embedded randomized trial.

Group Type EXPERIMENTAL

Proton Arm 1: Standard Proton Therapy

Intervention Type RADIATION

78.0 Gy (RBE) in 39 fractions

Hypofractionated Proton therapy

60.0 Gy (RBE) in 20 fractions This is Arm 2 of the embedded randomized trial.

Group Type EXPERIMENTAL

Proton Arm 2: Hypofractionated Proton Therapy

Intervention Type RADIATION

60.0 Gy (RBE) in 20 fractions

Interventions

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Standard of Care IMRT (Photon)

As this trial is pragmatic, all treatment will be standard of care.

Intervention Type RADIATION

Standard of Care Proton Therapy

As this trial is pragmatic, all treatment will be standard of care.

Intervention Type RADIATION

Proton Arm 1: Standard Proton Therapy

78.0 Gy (RBE) in 39 fractions

Intervention Type RADIATION

Proton Arm 2: Hypofractionated Proton Therapy

60.0 Gy (RBE) in 20 fractions

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of adenocarcinoma of the prostate.
* 30-85 years of age at the time of consent with a life expectancy estimation (LEE) of ≥ 8 years.
* Localized prostate cancer, as confirmed by staging with PSA, biopsy, Gleason score, DRE with or without mpMRI, and clinical stage.
* Very low-risk, low-risk, intermediate-risk, or high-risk disease based on NCCN Prostate Cancer Risk Group Guidelines and Joint AUA/ASTRO/SUO Guidelines.
* If patient has high-risk disease, nuclear medicine bone imaging must be performed to document the absence of overt metastatic disease in bones.
* ECOG/Zubrod Performance Status 0 - 2.
* Candidate for definitive prostate radiotherapy (either IMRT or proton).
* If patient is to be treated with IMRT, all treatment must be planned with IMRT; if patient is to be treated with protons, all treatment must be planned with protons (including pelvic nodes if treated).

Exclusion Criteria

* Findings of metastatic disease (nodal or distant, N1 or M1).
* Very high-risk prostate cancer based on NCCN Prostate Cancer Risk Group Guidelines and Joint AUA/ASTRO/SUO Guidelines.
* Prior procedures for treatment of prostate cancer, such as radical or robotic prostatectomy, high-intensity focused ultrasound, cryosurgery, or focal prostatectomy \[note that procedures used for benign prostatic hyperplasia symptoms, such as transurethral resection of the prostate (TURP) and GreenLight Laser Therapy, are acceptable\].
* Previous prostate cancer treatment with the exception of ADT according to NCCN guidelines.
* History of invasive rectal malignancy or other malignancy in the true pelvis (e.g. bladder, rectum, or reproductive organs), regardless of disease-free interval.
* Active inflammatory bowel disease (i.e., patients requiring medical interventions or who are symptomatic).
* Prior pelvic RT for any reason.
* Documented lack of psychological ability or general health permitting completion of the study requirements and required follow-up.
* Documented diminished capacity to understand the risks and benefits of participation in research and to autonomously provide informed consent.

In addition, because the embedded randomized controlled trial compares fractionation schemes, patients who are receiving pelvic node irradiation may not be enrolled on the randomized controlled trial.
Minimum Eligible Age

30 Years

Maximum Eligible Age

85 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Patient-Centered Outcomes Research Institute

OTHER

Sponsor Role collaborator

University of Florida

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nancy P. Mendenhall, MD

Role: PRINCIPAL_INVESTIGATOR

University of Florida

Locations

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University of Alabama at Birmingham (UAB)

Birmingham, Alabama, United States

Site Status

University of California San Diego

La Jolla, California, United States

Site Status

Proton Therapy Treatment Center - Loma Linda University

Loma Linda, California, United States

Site Status

Sutter Health

Roseville, California, United States

Site Status

California Protons Cancer Therapy Center

San Diego, California, United States

Site Status

Department of Radiation Oncology Davis Cancer Pavilion

Gainesville, Florida, United States

Site Status

University of Florida Proton Therapy Institute

Jacksonville, Florida, United States

Site Status

Ackerman Cancer Center

Jacksonville, Florida, United States

Site Status

Mayo Clinic

Jacksonville, Florida, United States

Site Status

University of Miami School of Medicine

Miami, Florida, United States

Site Status

Miami Cancer Institute

Miami, Florida, United States

Site Status

Orlando Health UF Health Center

Orlando, Florida, United States

Site Status

Winship Cancer Institute - Emory University

Atlanta, Georgia, United States

Site Status

University of Chicago

Chicago, Illinois, United States

Site Status

Northwestern Medicine Proton Center

Warrenville, Illinois, United States

Site Status

University of Kansas Medical Center

Lawrence, Kansas, United States

Site Status

University of Louisville

Louisville, Kentucky, United States

Site Status

Willis-Knighton Medical Center PTC

Shreveport, Louisiana, United States

Site Status

Johns Hopkins University

Baltimore, Maryland, United States

Site Status

University of Maryland

College Park, Maryland, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Karmanos Cancer Institute

Detroit, Michigan, United States

Site Status

Mayo Clinic Health System

Mankato, Minnesota, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

S Lee Kling Proton Therapy Center - Washington University Medical Center

St Louis, Missouri, United States

Site Status

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, United States

Site Status

Covenant Health

Somerset, New Jersey, United States

Site Status

New York Proton Center

New York, New York, United States

Site Status

Weill Cornell

New York, New York, United States

Site Status

The Duke University Health System

Durham, North Carolina, United States

Site Status

UNC- Rex Hospital

Raleigh, North Carolina, United States

Site Status

University of Cincinnati Medical PTC

Cincinnati, Ohio, United States

Site Status

Cleveland Clinic

Cleveland, Ohio, United States

Site Status

University Hospitals- Seidman Cancer Center

Cleveland, Ohio, United States

Site Status

Stephenson Cancer Center

Oklahoma City, Oklahoma, United States

Site Status

Oregon Health & Science University

Portland, Oregon, United States

Site Status

University of Pennsylvania--Penn Medicine

Philadelphia, Pennsylvania, United States

Site Status

Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Provision CARES Proton Therapy Center Knoxville

Knoxville, Tennessee, United States

Site Status

Texas Oncology

Austin, Texas, United States

Site Status

University of Texas MD Anderson Cancer Center

Houston, Texas, United States

Site Status

Texas Center for Proton Therapy

Irving, Texas, United States

Site Status

Texas Oncology - Longview

Longview, Texas, United States

Site Status

Texas Oncology - McKinney

McKinney, Texas, United States

Site Status

Texas Oncology - Plano West

Plano, Texas, United States

Site Status

Texas Oncology - Waco

Waco, Texas, United States

Site Status

University of Virginia

Charlottesville, Virginia, United States

Site Status

Inova Schar Cancer Institute

Fairfax, Virginia, United States

Site Status

Hampton University Proton Therapy Institute

Hampton, Virginia, United States

Site Status

Seattle Care Alliance/University of Washington

Seattle, Washington, United States

Site Status

Mayo Clinic Health System

Eau Claire, Wisconsin, United States

Site Status

Mayo Clinic Health System-Franciscan Healthcare

Sparta, Wisconsin, United States

Site Status

Countries

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United States

References

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NCCN Clinical Practical Guidelines in Oncology: Prostate Cancer. Version 2. 2018.

Reference Type BACKGROUND

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U.S. Preventive Services Task Force. Draft Recommendation Statement: Prostate Cancer: Screening. April 2017; https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementDraft/prostate-cancer-screening1. Accessed May 8, 2017.

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Other Identifiers

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PCORI-6312

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

IRB201801001

Identifier Type: OTHER

Identifier Source: secondary_id

OCR17881

Identifier Type: OTHER

Identifier Source: secondary_id

COMPPARE

Identifier Type: -

Identifier Source: org_study_id

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