Urine and Serum Concentrations of Pregnancy-Associated Compounds During Gestation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

245 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-24

Study Completion Date

2019-09-30

Brief Summary

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Investigators will collect serum and urine specimens from pregnant patients along the full pregnancy continuum, assay each specimen for selected placental proteins, and examine the relationships between concentrations of the proteins and gestational age as determined by ultrasound.

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Detailed Description

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Investigators will collect serum and urine specimens from pregnant patients along with ultrasound results and information about factors that may affect the concentrations of proteins or the estimation of gestational age. Investigators will obtain data across the full pregnancy continuum but we will over sample patients within five gestational weeks before and after the 10 week mark.

Investigators will assay each specimen for selected placental proteins (Human placental lactogen (HPL), Schwangerschaftsprotein 1 (SP1), Pregnancy-associated plasma protein A (PAPP-A), A Disintegrin and Metalloproteinase 12 (ADAM12), and Human chorionic gonadotropin (HGC)) and any other proteins of interest identified prior to running assays and will examine the relationships between concentrations of the proteins and gestational age as determined by ultrasound.

The goal is to identify at least one compound and a concentration threshold for that compound that can be used for differentiating pregnancies of less than 10 weeks in duration from later pregnancies.

Conditions

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Gestational Age

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Interventions

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Non-interventional Study

no interventions in this study, just specimen collection

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Has an intrauterine pregnancy confirmed by ultrasound
* Not known to have pregnancy-induced hypertension (preeclampsia) or diabetes
* Not known to have a nonviable pregnancy, a multiple pregnancy, a pregnancy with a chromosomal or fetal abnormality, or a pregnancy with growth restriction
* Not currently taking anticoagulants
* Not currently having clinically significant vaginal bleeding, unusual pelvic pain, or other symptom suggestive of a pregnancy complication
* No use of assisted reproductive technology to conceive the current pregnancy
* Not previously enrolled in this study

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No