Impact of DAA Uptake in Controlling HCV Epidemic and Modeling Interventions for HCV Elimination Among HIV-infected Persons in San Diego

NCT ID: NCT03551002

Last Updated: 2021-09-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

450 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2021-12-31

Brief Summary

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A retrospective and prospective study among people living with HIV (PLWH) that assesses hepatitis C (HCV) treatment uptake during periods before and after direct acting antivirals (DAA) introduction, and its impact on the HCV epidemic among PLWH.

Detailed Description

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A study that aims to quantify the state of DAA uptake and its impact on the HCV epidemic among PLWH in San Diego, and to characterize negative predictors of DAA treatment uptake among PLWH in San Diego. Retrospective and prospective data from UCSD Owen Clinic will be utilized to calculate HCV prevalence, primary incidence, and reinfection incidence. Using mathematical epidemic models, the study will assess levels of existing and scaled-up interventions necessary for HCV elimination from PLWH in San Diego.

Conditions

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Hepatitis C Hepatitis C, Chronic HIV/AIDS

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Retrospective

No interventions assigned to this group

Prospective

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Any adult (≥ 18 years) HIV-infected patient attending the UCSD Owen Clinic
* With history of acute or chronic HCV infection defined as having a detectable HCV viral load with or without a positive HCV antibody

Exclusion Criteria

* With no history of or current HCV infection defined as having a negative HCV antibody from 2008 to 2020
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of California, San Diego

OTHER

Sponsor Role lead

Responsible Party

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Edward Cachay, MD, MAS

Associate Professor of Clinical Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Edward Cachay, MD, MAS

Role: PRINCIPAL_INVESTIGATOR

University of California, San Diego

Locations

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Owen Clinic-University of California, San Diego

San Diego, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Edward Cachay, MD, MAS

Role: CONTACT

(619)543-3882

Facility Contacts

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Edward Cachay, MD, MAS

Role: primary

Other Identifiers

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171954

Identifier Type: OTHER

Identifier Source: secondary_id

IN-US-334-4481

Identifier Type: -

Identifier Source: org_study_id

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