Study Results
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View full resultsBasic Information
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ACTIVE_NOT_RECRUITING
257948 participants
OBSERVATIONAL
2016-01-31
2028-03-31
Brief Summary
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Detailed Description
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The cardiovascular theme clinical leads developed a standard target data model specification to capture the longitudinal record for patients who presented with a suspected acute coronary syndrome, characterised by the request of a troponin test (NHIC-Troponin Study). The data model was patient centric allowing for minor discrepancies between dataset areas such as missing discharges or test results returning outside of episodes of care. The model included 156 data points, grouped into demographics, cardiovascular risk factors, emergency department attendance and inpatient episodes, biochemistry, revascularisation and mortality. All patients were followed up on the NHS Spine Application, Summary Care Record until death or censoring on 1st April 2017.
This dataset comprised all patients who had a troponin measured at each of the five major academic centres between 2010 (2008 for University College Hospital) and 2017. The investigators identified a total of 257948 patient records who underwent troponin testing during the study period.
A Committee of Experts validates the protocol methodology and supervises the data management. A Steering Committee oversees study proposals including hypotheses, study design and statistical analyses including planned outcome measures.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Unselected cohort of patients who had a troponin measured
Patients who presented to hospital during the study period (2010-17) and had at least one troponin blood test measured.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
No
Sponsors
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Guy's and St Thomas' NHS Foundation Trust
OTHER
King's College Hospital NHS Trust
OTHER
Oxford University Hospitals NHS Trust
OTHER
University College London Hospitals
OTHER
University Hospital Southampton NHS Foundation Trust
OTHER
University Hospitals, Leicester
OTHER
University Hospitals Bristol and Weston NHS Foundation Trust
OTHER
Manchester University NHS Foundation Trust
OTHER_GOV
University Hospital Birmingham NHS Foundation Trust
OTHER
The Leeds Teaching Hospitals NHS Trust
OTHER
Blackpool Teaching Hospitals NHS Foundation Trust
OTHER
Imperial College London
OTHER
Responsible Party
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Jamil Mayet
Professor of Cardiology
Principal Investigators
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Jamil Mayet
Role: PRINCIPAL_INVESTIGATOR
Imperial College London
References
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Scott JK, Johnson T, Caskey FJ, Bailey P, Selman LE, Mulla A, Glampson B, Davies J, Papdimitriou D, Woods K, O'Gallagher K, Williams B, Asselbergs FW, Mayer EK, Lee R, Herbert C, Grant SW, Curzen N, Squire I, Kharbanda R, Shah A, Perera D, Patel RS, Channon K, Mayet J, Kaura A, Ben-Shlomo Y. Association between kidney function, frailty and receipt of invasive management after acute coronary syndrome. Open Heart. 2024 Oct 9;11(2):e002875. doi: 10.1136/openhrt-2024-002875.
Kaura A, Hartley A, Panoulas V, Glampson B, Shah ASV, Davies J, Mulla A, Woods K, Omigie J, Shah AD, Thursz MR, Elliott P, Hemmingway H, Williams B, Asselbergs FW, O'Sullivan M, Lord GM, Trickey A, Sterne JA, Haskard DO, Melikian N, Francis DP, Koenig W, Shah AM, Kharbanda R, Perera D, Patel RS, Channon KM, Mayet J, Khamis R. Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study. PLoS Med. 2022 Feb 22;19(2):e1003911. doi: 10.1371/journal.pmed.1003911. eCollection 2022 Feb.
Kaura A, Panoulas V, Glampson B, Davies J, Mulla A, Woods K, Omigie J, Shah AD, Channon KM, Weber JN, Thursz MR, Elliott P, Hemingway H, Williams B, Asselbergs FW, O'Sullivan M, Kharbanda R, Lord GM, Melikian N, Patel RS, Perera D, Shah AM, Francis DP, Mayet J. Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres. BMJ. 2019 Nov 20;367:l6055. doi: 10.1136/bmj.l6055.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Related Links
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Creating 'big data' from health records to improve care
Other Identifiers
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16/HRA/3327
Identifier Type: OTHER
Identifier Source: secondary_id
174052
Identifier Type: -
Identifier Source: org_study_id
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