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Prospective Registry of Outcomes and Management of Acute Ischaemic Syndromes

NCT ID: NCT00716352

Last Updated: 2008-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1340 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-03-31

Study Completion Date

2005-11-30

Brief Summary

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This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated, half received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months. Longer term follow up through the Office Of National Statistics will be performed.

Detailed Description

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This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated. A cluster randomised method was used and half of centres received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months and longer term follow up for mortality will be performed through the national databases.

Conditions

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Acute Coronary Syndromes Coronary Artery Disease

Keywords

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non-ST elevation acute coronary syndrome educational intervention evidence based practice guidelines

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Interventions

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Educational intervention programme

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. Ischaemic changes on the admission ECG (including patients with bundle branch block)
2. Elevated Troponin or cardiac enzymes on admission
3. Normal ECGs but with evidence of pre-existing coronary artery disease i.e., evidence of a prior history of MI, coronary revascularisation, coronary angiography demonstrating the presence of significant coronary stenosis or a stress test demonstrating ischaemia (treadmill, echo or nuclear scan)

Written informed consent

Exclusion Criteria

1. Patients with persistent ST elevation \>1mm in two or more contiguous leads on the ECG.
2. Patients treated with thrombolytic therapy, or for whom thrombolytic therapy was considered on admission.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sanofi

INDUSTRY

Sponsor Role collaborator

Bristol-Myers Squibb

INDUSTRY

Sponsor Role collaborator

Royal Brompton & Harefield NHS Foundation Trust

OTHER

Sponsor Role lead

Principal Investigators

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Marcus Flather

Role: PRINCIPAL_INVESTIGATOR

Royal Brompton & Harefield NHS Trust, Imperial College London

Locations

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University Hospital Aintree

Aintree, , United Kingdom

Site Status

Monklands Hospital

Airdrie, , United Kingdom

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Antrim Hospital

Antrim, , United Kingdom

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Barnet General Hospital

Barnet, , United Kingdom

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Barnsley District General Hospital

Barnsley, , United Kingdom

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Basildon Hospital

Basildon, , United Kingdom

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North Hampshire Hospital

Basingstoke, , United Kingdom

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Mater Infirmorum Hospital

Belfast, , United Kingdom

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Royal Victoria Hospital

Belfast, , United Kingdom

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Birmingham Heartlands Hospital

Birmingham, , United Kingdom

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Bridlington And District Hospital

Bridlington, , United Kingdom

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The Royal Sussex County Hospital

Brighton, , United Kingdom

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Cumberland Infirmary

Carlisle, , United Kingdom

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Leighton Hospital

Crewe, , United Kingdom

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Darent Valley Hospital

Dartford, , United Kingdom

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Eastbourne District General Hospital

Eastbourne, , United Kingdom

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Western Infirmary

Glasgow, , United Kingdom

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Withybush General Hospital

Haverfordwest, , United Kingdom

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Altnagelvin Area Hospital

Londonderry, , United Kingdom

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Luton and Dunstable Hospital

Luton, , United Kingdom

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Macclesfield District General Hospital

Macclesfield, , United Kingdom

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Northampton General Hospital

Northampton, , United Kingdom

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Royal Alexandra Hospital

Paisley, , United Kingdom

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Pontefract General Infirmary

Pontefract, , United Kingdom

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Whiston Hospital

Prescot, , United Kingdom

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Oldchurch Hospital

Romford, , United Kingdom

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Rotherham District General Hospital

Rotherham, , United Kingdom

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Hope Hospital

Salford, , United Kingdom

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University Hospital Of North Tees

Stockton-on-Tees, , United Kingdom

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University Hospital Of North Staffordshire

Stoke-on-Trent, , United Kingdom

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Wordsley Hospital

Stourbridge, , United Kingdom

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Taunton and Somerset Hospital

Taunton, , United Kingdom

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Torbay Hospital

Torquay, , United Kingdom

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Pinderfields General Hospital

Wakefield, , United Kingdom

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West Cumberland Hospital

Whitehaven, , United Kingdom

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Royal Albert Edward Infirmary

Wigan, , United Kingdom

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Wrexham Maelor Hospital

Wrexham, , United Kingdom

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Countries

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United Kingdom

Related Links

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http://www.cteu.org

Central co-ordinating centre website

Other Identifiers

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MREC/03/10/48

Identifier Type: -

Identifier Source: org_study_id