The Effects of an Acute Bout of Exercise on Alcohol and Cocaine Craving

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-07-05

Study Completion Date

2020-11-30

Brief Summary

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The study is a crossover randomised controlled trial. Alcohol or cocaine dependent participants will be recruited from inpatient and outpatient psychiatric treatment centres, on the approval of their treating physician. A healthy control group will be recruited using online advertising. All participants will undergo each of three conditions in a randomised order; 1) 20 minutes of cycle ergometry at 50-60% of maximum heart rate; 2) 20 minutes of exercise at 70-80% of maximum heart rate; 3) 20 minutes of quiet reading. Immediately before and after each condition, participants will be asked to complete a computerised Stroop test, watch a film containing substance-related images, and self-report craving levels. During the Stroop test and film viewing, participants' neural activity will be measured via functional near-infrared spectroscopy

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Detailed Description

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The aim of this study is to examine whether, following acute exercise bouts at moderate and high intensities, reduced craving and increased inhibitory control can be observed in alcohol or cocaine dependent individuals. As the focus of this study is the potential of exercise to be integrated into treatment, individuals in treatment for their dependence, who have been abstinent for a short period, will be recruited.

Conditions

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Substance Use Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Moderate exercise

20 minutes of cycle ergometry at 50 - 60% of heart rate max.

Group Type EXPERIMENTAL

Moderate exercise

Intervention Type OTHER

20 minutes of cycle ergometry at 50-60% of heart rate max

Intense Exercise

20 minutes of cycle ergometry at 70 - 80% of heart rate max.

Group Type EXPERIMENTAL

Intense exercise

Intervention Type OTHER

20 minutes of cycle ergometry at 70-80% of heart rate max

Rest

20 minutes of seated reading.

Group Type ACTIVE_COMPARATOR

Reading

Intervention Type OTHER

20 minutes of seated reading

Interventions

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Moderate exercise

20 minutes of cycle ergometry at 50-60% of heart rate max

Intervention Type OTHER

Intense exercise

20 minutes of cycle ergometry at 70-80% of heart rate max

Intervention Type OTHER

Reading

20 minutes of seated reading

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

For alcohol or cocaine dependent participants:

* meeting three or more of the DSM-IV criteria for substance dependence (as determined by treating physician);
* minimum of 20 days and maximum of 40 days abstinence from substance of dependence;
* able to understand and complete the informed consent;
* able to travel to study site independently, as confirmed by the treating psychiatrist;
* assessed for physical and mental fitness by treating physician and cleared to take part in the study;
* fewer than 3 hours of physical exercise or sport per week;

For healthy controls:

* fewer than 3 hours of physical exercise or sport per week;
* no history of problematic alcohol or illicit drug consumption.