Double Filtration Plasmapheresis (DFPP) and Lipid Metabolism

NCT ID: NCT03491956

Last Updated: 2021-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-01

Study Completion Date

2021-04-01

Brief Summary

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Little clinic trials showed that Double Filtration Plasmapheresis (DFPP) could improve lipid metabolism, however, whether DFPP can improve platelet function and recover Endothelial function is unknown. In this study, we try to confirm the hypothesis that DFPP can improve endothelial function in hyperlipidemia patients.

Detailed Description

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Conditions

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DFPP and Platelet Function

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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DFPP group

self contrast (before and after DFPP)

Group Type OTHER

DFPP

Intervention Type DEVICE

Lipid levels,platelet function,and platelet RNA sequencing in hyperlipidemia patients before and after DFPP

Interventions

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DFPP

Lipid levels,platelet function,and platelet RNA sequencing in hyperlipidemia patients before and after DFPP

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. hyperlipidemia

Exclusion Criteria

1. Severe liver and kidney dysfunction
2. Severe cardiopulmonary insufficiency
3. tumor
4. pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Pudong Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jin HM, MD

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bo Yu, doctor

Role: PRINCIPAL_INVESTIGATOR

Shanghai Pudong Hospital

Locations

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Shanghai Pudong Hospital

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Huimin Jin, doctor

Role: CONTACT

13917232915

Facility Contacts

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Huimin Jin, doctor

Role: primary

References

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Zhang XM, Gu YH, Deng H, Xu ZQ, Zhong ZY, Lyu XJ, Jin HM, Yang XH. Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs. Front Cardiovasc Med. 2021 Jul 7;8:691336. doi: 10.3389/fcvm.2021.691336. eCollection 2021.

Reference Type DERIVED
PMID: 34307504 (View on PubMed)

Other Identifiers

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ShanghaiPudongH2

Identifier Type: -

Identifier Source: org_study_id

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