Genetic Variants and Non-genetic Variables and Postoperative Nausea and Vomiting
NCT ID: NCT03490175
Last Updated: 2020-04-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
2778 participants
OBSERVATIONAL
2011-01-31
2019-12-31
Brief Summary
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Detailed Description
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Surgery and anesthesia are related to unwanted adverse events, side effects and postoperative discomfort. Postoperative nausea and vomiting are frequent and the question arises which patient is at specific risk for these sequelae. Some predisposing factors for PONV are well described, e.g. female sex, non-smoking status and postoperative opioids. Some drugs used for anesthesia as well as surgery related variables might induce PONV.
In this prospective association study patient related variables, surgical and anesthesia related variables as well as genetic variants of several candidate genes will be investigated in a well-described patient cohort presenting for scheduled surgery.
Objective
The aim of this study is to investigate a possible association of non-genetic variables and genetic variants with PONV.
Methods
Prospective association study performed in patients recovering form elective surgery and anesthesia.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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All patients
Patients undergoing general anesthesia for elective surgery
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Written informed consent
* Elective surgery
Exclusion Criteria
* Cognitive impairment
18 Years
ALL
Yes
Sponsors
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Insel Gruppe AG, University Hospital Bern
OTHER
Responsible Party
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Principal Investigators
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Ulrike Stamer, Prof. MD
Role: STUDY_CHAIR
Department of Anaestheisology and Pain Medicine, Inselspital, University of Bern
Ulrike M Stamer, MD
Role: PRINCIPAL_INVESTIGATOR
Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern
Locations
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Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern
Bern, , Switzerland
Countries
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References
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Stamer UM, Schmutz M, Wen T, Banz V, Lippuner C, Zhang L, Steffens M, Stuber F. A serotonin transporter polymorphism is associated with postoperative nausea and vomiting: An observational study in two different patient cohorts. Eur J Anaesthesiol. 2019 Aug;36(8):566-574. doi: 10.1097/EJA.0000000000001014.
Other Identifiers
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041/09b PONV
Identifier Type: -
Identifier Source: org_study_id
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