The Relationship Between Fetal Baseline Heart-rate and the Level of Acetyl-choline Esterase in Fetal Blood
NCT ID: NCT03478267
Last Updated: 2022-05-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
101 participants
OBSERVATIONAL
2019-02-17
2021-03-01
Brief Summary
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Detailed Description
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Patients will be divided into 2 equal groups according to fetal baseline heart rate:
1. st group-fetal heart rate between 110-130 beats per minute (bpm).
2. nd group-fetal heart rate between 140-160 bpm. A blood sample will be acquired from the parturient and the umbilical cord as well as a sample from the placenta will be obtained. Levels of Acetyl Choline Esterase (AChE) will be determined from all aforementioned samples. Statistical correlation between fetal baseline heart rate and fetal and maternal AChE levels will be assessed.
Data regarding demographic, medical and obstetric information of the participants will be obtained from the hospital's electronic records.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Fetal heart rate 110-130 bpm
Pregnancies in which the fetal baseline heart rate is between 110 beats per minute and 130 beats per minute.
AChE levels
AChE levels in peripheral blood tests from maternal blood, fetal umbilical cord and placenta.
Fetal heart rate 140-160 bpm
Pregnancies in which the fetal baseline heart rate is between 140 beats per minute and 160 beats per minute.
AChE levels
AChE levels in peripheral blood tests from maternal blood, fetal umbilical cord and placenta.
Interventions
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AChE levels
AChE levels in peripheral blood tests from maternal blood, fetal umbilical cord and placenta.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. Maternal bradycardic (\<60) or tachycardic (\>100) resting heart rate.
3. Fetal bradycardia (\<110) or tachycardia (\>160).
4. Suspected chorioamnionitis
5. Maternal diseases which can affect her heart rate such as:
1. Cardiac disease (including arrhythmias)
2. Diseases of the thyroid gland
3. Rheumatic diseases
6. Use of medication which alters heart rate such as:
1. Beta blockers
2. Beta agonists
3. Cocaine, amphetamines
7. Use of Pethidine and Phenergan during delivery
18 Years
44 Years
FEMALE
No
Sponsors
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Rambam Health Care Campus
OTHER
Responsible Party
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Vered Lamhot MD
Primary investigator
Principal Investigators
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Vered Lamhot, MD
Role: PRINCIPAL_INVESTIGATOR
Rambam Health Care Campus
Locations
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Rambam hospital
Haifa, , Israel
Countries
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Other Identifiers
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0584-16-RMB
Identifier Type: -
Identifier Source: org_study_id
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