Serotonin Levels in Atopic Dermatitis Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-01

Study Completion Date

2019-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease of unknown aetiology. Global prevalence rates range from 1%-20%.AD is often worsened by stress and anxiety.Plasma levels of 5-HT were found to be positively correlated with the disease severity.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Chronic Pruritus of Unknown Origin

NCT03841331

Pruritus

COMPLETED PHASE2

Combination Therapy in Patients With Depression

NCT00485862

Depressive Symptoms

COMPLETED PHASE4

An Eight-week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression

NCT00256113

Depressive Disorder

COMPLETED PHASE3

Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania

NCT00118014

Impulse Control Disorders

COMPLETED PHASE4

An Eight-Week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression

NCT00250627

Depressive Disorder

COMPLETED PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease of unknown aetiology. The condition typically starts in infancy with changing presentations over the years. Incessant pruritus is the main symptom.

Main findings include: xerosis, eczematous lesions, Ig E reactivity, relapsing course and personal or family history of other atopic diatheses .Global prevalence rates range from 1%-20%.

AD is often worsened by stress and anxiety. Moreover, a mutual relationship between the neuroendocrine system and the immune system; including the skin has been suggested. Different mediators are responsible for this relation. Serotonin is considered as one of the most important responsible mediators (5-hydroxy-tryptamine; 5-HT) .

Patients with AD have been reported to have high serum levels of 5-HT. Moreover, plasma levels of 5-HT were found to be positively correlated with the disease severity. However and to the best of the investigators' knowledge, no studies have addressed this point in Egypt.

Treatment of AD includes: Elimination of triggers, emollients, topical therapies, and systemic modalities including SSRIs (Selective Serotonin Reuptake Inhibitors) and TCAs (Tricyclic Antidepressants) in certain cases. SSRIs block the reuptake of serotonin, thus increase the concentration of serotonin within synaptic clefts. The mechanism of action in relation to pruritus is not understood, but SSRIs have been used to treat atopic dermatitis associated pruritus

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Dermatologic Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients withf Atopic Dermatitis

Diagnosis is based upon American Academy of Dermatology recommendations for Diagnostic Criteria 2014.

Serum serotonin level

Intervention Type DIAGNOSTIC_TEST

blood sample will be obtained to evaluate serum level of serotonin

healthy volunteers

Normal individuals not complaining of any dermatological diseases

Serum serotonin level

Intervention Type DIAGNOSTIC_TEST

blood sample will be obtained to evaluate serum level of serotonin

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Serum serotonin level

blood sample will be obtained to evaluate serum level of serotonin

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* All patients with the clinical diagnosis of AD.
* Age more than 2

Exclusion Criteria

* Age less than 2 years.
* Any concomitant systemic or dermatological disease.
* Patients on any topical or systemic treatment during the past one month.
* Uncooperative patients.
* Refusal to participate

Minimum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes