Contrast Nephropathy in Type 2 Diabetes

NCT ID: NCT03470454

Last Updated: 2020-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-07-01

Study Completion Date

2018-11-30

Brief Summary

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To study the effect of radiocontrast material on kidney functions in diabetics with microalbuminuria

Detailed Description

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Study design:

This study will be an observational prospective cohort study.

Study population:

Diabetics undergoing any intervention using radiocontrast material for any medical indication in Fayoum universiy hospital will be selected. There will be two arms of the study,each arm will contain 20 patients first arm diabetics on linagelptin, second arm diabetics on other DPP4 inhibitors.

Data collection:

Patients will be subjected to; full clinical examination,waist hip ratio assessment,BMI assessment fasting blood glucose,Serum uric acid, urine ACR, eGFR will be done before and after the investigation.

Conditions

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Kidney Function Affection Upon Exposure to Radiocontrast Diabetes Microalbuminuria

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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diabetics on linagelptin

Diabetic patients were given linagelptin for blood glucose control

Linagliptin Oral Tablet

Intervention Type DRUG

Linagliptin for blood glucose control

diabetics on other DPP4 inhibitors

Diabetic pateints were given other DPP4 inhibitors eg: vlidagliptin for blood glucose control

Linagliptin Oral Tablet

Intervention Type DRUG

Linagliptin for blood glucose control

Interventions

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Linagliptin Oral Tablet

Linagliptin for blood glucose control

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diabetics on DPP 4 inhibitor treatment

Exclusion Criteria

* Diabetics on insulin
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role collaborator

Fayoum University

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Abdelkawi Hammad

Lecturer of internal medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Usama A Sharafeldin, MD

Role: STUDY_DIRECTOR

Cairo University

Locations

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Faculty of medicine Fayoum univesity

Al Fayyum, , Egypt

Site Status

Fayoum University

Al Fayyum, , Egypt

Site Status

Countries

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Egypt

References

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Fayed A, Hammad AA, Abdulazim DO, Hammad H, Amin M, Elhadidy S, Salem MM, ElAzim IMA, Zsom L, Csongradi E, Soliman KM, Sharaf El Din UA. Is the combination of linagliptin and allopurinol better prophylaxis against post-contrast acute kidney injury? A multicenter prospective randomized controlled study. Ren Fail. 2023 Dec;45(1):2194434. doi: 10.1080/0886022X.2023.2194434.

Reference Type DERIVED
PMID: 36974638 (View on PubMed)

Other Identifiers

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VCG 4

Identifier Type: -

Identifier Source: org_study_id

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