Multicenter Study of Impulse Oscillometry in Chinese

NCT ID: NCT03467880

Last Updated: 2018-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

4000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-09-30

Study Completion Date

2018-12-31

Brief Summary

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The purpose of this study is to establish the reference values of impulse oscillometry (IOS) in healthy Chinese, and compare the indices of IOS in patients with lung disease, such as chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease (ILD), and upper airway Obstruction (UAO).

Detailed Description

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Conditions

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Healthy Subjects Chronic Obstructive Pulmonary Disease Asthma Interstitial Lung Disease Upper Airway Obstruction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Healthy subjects

Healthy subjects.

Clinical Observation

Intervention Type OTHER

No treatment given but observation with IOS

Chronic obstructive pulmonary disease

Patience with chronic obstructive pulmonary disease.

Clinical Observation

Intervention Type OTHER

No treatment given but observation with IOS

Asthma

Patience with asthma.

Clinical Observation

Intervention Type OTHER

No treatment given but observation with IOS

Interstitial lung disease

Patience with interstitial lung disease.

Clinical Observation

Intervention Type OTHER

No treatment given but observation with IOS

Upper airway obstruction

Patience with upper airway obstruction.

Clinical Observation

Intervention Type OTHER

No treatment given but observation with IOS

Interventions

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Clinical Observation

No treatment given but observation with IOS

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* life-long non-smokers
* no symptoms and history of chronic cardiopulmonary diseases (chronic bronchitis, asthma, lung cancer, pulmonary fibrosis, pulmonary tuberculosis, chronic heart diseases, etc.)
* no abnormal findings on physical examination
* written informed consent was obtained


* Diagnosis of chronic obstructive pulmonary disease (COPD), as classified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines and post-bronchodilator FEV1/FVC (forced vital capacity) \< 70%.


* Diagnosis of asthma, as classified by national and international asthma guidelines.


* ILD diagnosis confirmed by lung biopsy, X ray or BALF analysis.


* Diagnosis of UAO.

Exclusion Criteria

* upper or lower respiratory infection within 4 weeks
* long-term exposure to harmful gas or particles
* using β-blocker for treatment
* pregnant women, epileptic
* other diseases or surgeries potentially affecting lung function
Minimum Eligible Age

4 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Beijing Hospital

OTHER_GOV

Sponsor Role collaborator

Beijing Children's Hospital

OTHER

Sponsor Role collaborator

Shanghai Zhongshan Hospital

OTHER

Sponsor Role collaborator

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role collaborator

West China Hospital

OTHER

Sponsor Role collaborator

Tongji Hospital

OTHER

Sponsor Role collaborator

Third Military Medical University

OTHER

Sponsor Role collaborator

Xiangya Hospital of Central South University

OTHER

Sponsor Role collaborator

People's Hospital of Anshun City of Guizhou Province

OTHER

Sponsor Role collaborator

Shanghai Pulmonary Hospital, Shanghai, China

OTHER

Sponsor Role collaborator

Beijing Chao Yang Hospital

OTHER

Sponsor Role collaborator

Guangzhou Institute of Respiratory Disease

OTHER

Sponsor Role lead

Responsible Party

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Jinping Zheng

Vice-director

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jinping Zheng, MD

Role: STUDY_CHAIR

State Key Laboratory of Respiratory Disease,China Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University

Locations

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Beijing Hospital

Beijing, , China

Site Status RECRUITING

State Key Laboratory of Respiratory Disease,China Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University

Guangzhou, , China

Site Status NOT_YET_RECRUITING

Countries

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China

Central Contacts

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Jinping Zheng, MD

Role: CONTACT

+86-20-83062729

Facility Contacts

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Yimeng Yang

Role: primary

+86 13911738389

Jinping Zheng, MD

Role: primary

+86-20-83062729

References

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Liang XL, Gao Y, Guan WJ, Du J, Chen L, Han W, Liu JM, Lu Y, Peng Y, Zhao BR, Wang T, Zheng JP. Reference values of respiratory impedance with impulse oscillometry in healthy Chinese adults. J Thorac Dis. 2021 Jun;13(6):3680-3691. doi: 10.21037/jtd-20-3376.

Reference Type DERIVED
PMID: 34277060 (View on PubMed)

Other Identifiers

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GIRD201536

Identifier Type: -

Identifier Source: org_study_id

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