Alpine vs. Xpedition: Evaluation of Stent Delivery System

NCT ID: NCT03451617

Last Updated: 2018-03-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

500 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-05

Study Completion Date

2020-10-05

Brief Summary

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To evaluate and compare the performance of two stent delivery systems for percutaneous coronary intervention with everolimus-eluting stent.

Detailed Description

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Rationale: The current gold standard for percutaneous coronary intervention (PCI) is the second generation drug-eluting stent (DES). The most commonly used DES is the everolimus-eluting stent (EES). New stent delivery systems for PCI with EES are developed to optimize strength, flexibility and pushability of the catheter. The effect on procedural time of new stent delivery systems has not yet been investigated in clinical practice.

Objective: To evaluate and compare the performance of two stent delivery systems for PCI with EES.

Study design: Randomized comparative trial with 500 patients in the University Medical Center Groningen (UMCG).

Study population: All patients undergoing PCI with EES, aged 18 years or older, will be considered for eligibility. Patients will be excluded when scheduled for chronic total occlusion (CTO) PCI or if verbal informed consent cannot be obtained.

Intervention: The first group will undergo PCI with the XIENCE EES using the Alpine stent delivery system, the second group will undergo PCI with the Xpedition stent delivery system.

Main study parameters/endpoints: The primary endpoint is the proportion of procedures with crossing time (from introduction of guidewire to stent deployment) longer than 30 minutes. Secondary endpoints include procedural time (from heparin administration to removal of catheter sheath, mins), use of additional materials, total procedural costs, radiation dose (μGym2), radiation time (mins), and contrast dose (ml).

Conditions

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Percutaneous Coronary Intervention

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Xpedition stent delivery system

Group Type OTHER

Stent delivery with Xpedition

Intervention Type DEVICE

Use of Xpedition stent delivery system to implant the XIENCE stent

Alpine stent delivery system

Group Type OTHER

Stent delivery with Alpine

Intervention Type DEVICE

Use of Alpine stent delivery system to implant the XIENCE stent

Interventions

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Stent delivery with Xpedition

Use of Xpedition stent delivery system to implant the XIENCE stent

Intervention Type DEVICE

Stent delivery with Alpine

Use of Alpine stent delivery system to implant the XIENCE stent

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* All patients undergoing PCI with EES, aged 18 years or older

Exclusion Criteria

* Chronic total occlusion (CTO) PCI
* Inability to obtain (verbal) informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott

INDUSTRY

Sponsor Role collaborator

University of Groningen

OTHER

Sponsor Role lead

Responsible Party

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Pim van der Harst

Prof. Dr. P. van der Harst

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Medical Center Groningen

Groningen, , Netherlands

Site Status RECRUITING

Countries

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Netherlands

Central Contacts

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Pim van der Harst, Prof. Dr.

Role: CONTACT

+31 50 3612355

Facility Contacts

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Pim van der Harst, Prof. Dr.

Role: primary

Other Identifiers

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201600966

Identifier Type: -

Identifier Source: org_study_id

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