Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2018-05-01
2018-09-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Control
Patients without asthma or aspirin intolerance who may or may not react to alcoholic beverages
Water
Serum and urine markers will be obtained after drinking 5 oz of water
Red wine
Serum and urine markers will be obtained after drinking 5 oz of water
Polyphenolic Compounds
Serum and urine markers will be obtained after consuming 100 mg of provinols powder
Aspirin Tolerant Asthma
Patients with asthma who are tolerant to aspirin and/or other NSAIDs and note sensitivity to alcoholic beverages
Water
Serum and urine markers will be obtained after drinking 5 oz of water
Red wine
Serum and urine markers will be obtained after drinking 5 oz of water
Polyphenolic Compounds
Serum and urine markers will be obtained after consuming 100 mg of provinols powder
Aspirin Intolerant Asthma / AERD
Patients with AERD who note sensitivity to alcoholic beverages
Water
Serum and urine markers will be obtained after drinking 5 oz of water
Red wine
Serum and urine markers will be obtained after drinking 5 oz of water
Polyphenolic Compounds
Serum and urine markers will be obtained after consuming 100 mg of provinols powder
Interventions
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Water
Serum and urine markers will be obtained after drinking 5 oz of water
Red wine
Serum and urine markers will be obtained after drinking 5 oz of water
Polyphenolic Compounds
Serum and urine markers will be obtained after consuming 100 mg of provinols powder
Eligibility Criteria
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Inclusion Criteria
* Aspirin Tolerant Asthma and AERD arms must note a sensitivity to alcoholic beverages
Exclusion Criteria
* Mastocytosis
* Alcoholism
* Prior severe respiratory reaction to alcohol consumption
* Current pregnancy
* Monoamine Oxidase Inhibitor (MAOI) use
* Age under 21
* Use of leukotriene modifier 1 week before study intervention
* Having undergone and maintained aspirin desensitization
21 Years
ALL
Yes
Sponsors
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University of Virginia
OTHER
Responsible Party
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Principal Investigators
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Spencer C Payne, MD
Role: PRINCIPAL_INVESTIGATOR
University of Virginia
Locations
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University of Virginia
Charlottesville, Virginia, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Cardet JC, White AA, Barrett NA, Feldweg AM, Wickner PG, Savage J, Bhattacharyya N, Laidlaw TM. Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2014 Mar-Apr;2(2):208-13.. doi: 10.1016/j.jaip.2013.12.003.
Payne SC. Re: Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2014 Sep-Oct;2(5):644. doi: 10.1016/j.jaip.2014.05.003. No abstract available.
Other Identifiers
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20382
Identifier Type: -
Identifier Source: org_study_id
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