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Effects of Red Wine and Cognac on Coronary Circulation

NCT ID: NCT00330213

Last Updated: 2006-05-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-10-31

Study Completion Date

2005-04-30

Brief Summary

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Red wine consumption is associated with reduced cardiovascular disease mortality, and the cardioprotective properties may be partly related to its ability to improve endothelial function. The purpose of this study was to determine whether moderate doses of red wine, de-alcoholized red wine and cognac improve coronary flow reserve.

Detailed Description

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Moderate consumption of red wine is associated with reduced coronary artery disease mortality. Cardioprotective effects of red wine may be partly related to its ability to improve endothelial function. Red wine increases endothelium-dependent flow-mediated dilatation of the brachial artery acutely after ingestion. Moreover, a heavy dose of red wine (ethanol 1.0 g/kg) has been shown to increase coronary flow reserve (CFR) as measured with transthoracic Doppler echocardiography. CFR depicts the relative increase of coronary blood flow in response to maximal myocardial hyperemia induced by adenosine. It is reduced in atherosclerosis and various conditions associated with the dysfunction of coronary microcirculation, such as diabetes and hypercholesterolemia.

Both ethanol and antioxidative polyphenols have been implicated in beneficial endothelial effects of red wine. However, their relative contributions remain uncertain in vivo. It has been suggested that red wine has stronger vasoactive properties than other alcohol beverages, and even de-alcoholized red wine may be sufficient to improve flow-mediated dilatation of the brachial artery. Cognac is also known to contain polyphenols, but its effects on coronary circulation have not been evaluated.

The purpose of this randomized controlled cross-over study was to determine with transthoracic echocardiography whether moderate doses of red wine improve CFR in response to adenosine in healthy humans. We also studied contributions of ethanol and antioxidants by comparing the effects of equal doses of alcoholic and de-alcoholized red wine, and cognac on the plasma antioxidant capacity and CFR.

Conditions

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Healthy

Keywords

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transthoracic echocardiography red wine cognac coronary reactivity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Interventions

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red wine and cognac consumption

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* healthy males

Exclusion Criteria

* smoking, medication of any kind
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Tampere University

OTHER

Sponsor Role collaborator

University of Turku

OTHER

Sponsor Role lead

Principal Investigators

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Tuomas O Kiviniemi, MD

Role: PRINCIPAL_INVESTIGATOR

Dept. Clinical Physiology and Nuclear Medicine, Turku University Hospital

Locations

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Dept. Clinical Physiology and Nuclear Medicine, Turku University Hospital

Turku, , Finland

Site Status

Countries

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Finland

References

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Kiviniemi TO, Saraste M, Koskenvuo JW, Airaksinen KE, Toikka JO, Saraste A, Parkka JP, Hartiala JJ. Coronary artery diameter can be assessed reliably with transthoracic echocardiography. Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1515-20. doi: 10.1152/ajpheart.00819.2003. Epub 2003 Dec 4.

Reference Type BACKGROUND
PMID: 14656707 (View on PubMed)

Kiviniemi TO, Saraste A, Toikka JO, Saraste M, Raitakari OT, Parkka JP, Lehtimaki T, Hartiala JJ, Viikari J, Koskenvuo JW. Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men. Cardiovasc Ultrasound. 2008 Jun 3;6:25. doi: 10.1186/1476-7120-6-25.

Reference Type DERIVED
PMID: 18522727 (View on PubMed)

Other Identifiers

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KLF-RW-06

Identifier Type: -

Identifier Source: org_study_id