Optimization of PK/PD Target Attainment for Ceftriaxone in Critically Ill Patients With Community-acquired Pneumonia.

NCT ID: NCT03438981

Last Updated: 2021-04-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-01-31

Study Completion Date

2019-07-31

Brief Summary

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WP2.1. PK/PD target attainment Plasma exposure ELF exposure WP2.2. Predictive dosing algorithm WP2.3. ECMO subset

Detailed Description

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First, the investigators will document exposure to ceftriaxone in plasma and epithelial lining fluid.

Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed.

Finally in a small subset of ECMO patients PK exposure will be explored.

Conditions

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Pharmacokinetics Critical Illness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Pneumonia
* Admitted to an ICU ward
* Treated with ceftriaxone

Exclusion Criteria

* Pregnancy
* DNR code 2-3
* Renal replacement therapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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KU Leuven

OTHER

Sponsor Role collaborator

Universitaire Ziekenhuizen KU Leuven

OTHER

Sponsor Role lead

Responsible Party

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Matthias Gijsen

PharmD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Isabel Spriet, PhD PharmD

Role: STUDY_DIRECTOR

[email protected]

Locations

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UZLeuven

Leuven, , Belgium

Site Status

Countries

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Belgium

Other Identifiers

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ML8457

Identifier Type: -

Identifier Source: org_study_id

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