Atrial and Ventricular Wall Stress During Breathing

NCT ID: NCT03436030

Last Updated: 2019-04-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-11-18

Study Completion Date

2018-04-30

Brief Summary

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Healthy reclining adult volunteers, with Valsalva manoeuver, Muller manoeuver, light continuous positive airway pressure by mask, passive leg raising, and maximal hand-grip. Ultrasound heart images captured before and during.

Detailed Description

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With focus on atrial wall strain and strain-rate, In healthy volunteer adult subjects, heart ultrasound is recorded during resting, Valsalva manoeuver, Muller manoeuver, passive leg raising, and handgrip. Echocardiographic recordings are made before and during each intervention. Participants are otherwise resting in a reclined position.

Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Healthy reclining adult volunteers, with Valsalva manoeuver, Muller manoeuver, light continuous positive airway pressure by mask, passive leg raising, and maximal hand-grip. Ultrasound heart images captured before and during.
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Single arm, breathing manuevers

All subjects perform/undergo Valsalva, Muller, CPAP, hand grip, and passive leg raise, with ultrasound examination of heart recorded before and during the manoeuvre.

Group Type EXPERIMENTAL

Simple breathing manuevers during brief echocardiographic imaging

Intervention Type OTHER

Valsalva, Muller, light mask CPAP, leg raising, hand grip.

Interventions

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Simple breathing manuevers during brief echocardiographic imaging

Valsalva, Muller, light mask CPAP, leg raising, hand grip.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* healthy adults

Exclusion Criteria

* known heart or lung disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Region Västerbotten

OTHER_GOV

Sponsor Role collaborator

Umeå University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Umeå University, and the University Hospital of Umeå

Umeå, , Sweden

Site Status

Countries

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Sweden

References

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Gottfridsson P, A'Roch R, Lindqvist P, Law L, Myrberg T, Hultin M, A'Roch A, Haney M. Left atrial contraction strain and controlled preload alterations, a study in healthy individuals. Cardiovasc Ultrasound. 2022 Mar 30;20(1):8. doi: 10.1186/s12947-022-00278-1.

Reference Type DERIVED
PMID: 35354482 (View on PubMed)

Other Identifiers

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2017-327-31M

Identifier Type: -

Identifier Source: org_study_id

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