The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study

NCT ID: NCT03424668

Last Updated: 2019-04-16

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Total Enrollment: 25639 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 1992-01-01
• Study Completion Date: 2040-12-31

Brief Summary

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease.

Detailed Description

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease. Detailed data on sociodemographic, lifestyle, medical and family history were collected and a biological sample bank including urine and blood samples established. Participants have been followed up through repeat examinations, mailed questionnaires as well as through record linkage with routine health records including death certification by cause, cancer registration and hospital admissions by cause till present.

Conditions

Neoplasms; Cardiovascular Diseases; Death

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

diet

lifestyle factors

Intervention Type: BEHAVIORAL

Other Intervention Names

physical activity

Eligibility Criteria

Inclusion Criteria

• Willing to participate
• On general practice age sex registers in Norfolk, United Kingdom in 1993-1997

Exclusion Criteria

• Not willing to participate in study
• terminal illness

• Minimum Eligible Age: 39 Years
• Maximum Eligible Age: 79 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Medical Research Council

OTHER_GOV

Sponsor Role: collaborator

Cancer Research UK

OTHER

Sponsor Role: collaborator

University of Cambridge

OTHER

Sponsor Role: lead

Responsible Party

Kay-Tee Khaw

Professor of Clinical Gerontology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Nicholas Wareham, MBBS

Role: PRINCIPAL_INVESTIGATOR

University of Cambridge

Kay-Tee Khaw, MBBChir

Role: PRINCIPAL_INVESTIGATOR

University of Cambridge

References

Day N, Oakes S, Luben R, Khaw KT, Bingham S, Welch A, Wareham N. EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. Br J Cancer. 1999 Jul;80 Suppl 1:95-103. No abstract available.

Reference Type: BACKGROUND

PMID: 10466767 (View on PubMed)

Bingham SA, Welch AA, McTaggart A, Mulligan AA, Runswick SA, Luben R, Oakes S, Khaw KT, Wareham N, Day NE. Nutritional methods in the European Prospective Investigation of Cancer in Norfolk. Public Health Nutr. 2001 Jun;4(3):847-58. doi: 10.1079/phn2000102.

Reference Type: BACKGROUND

PMID: 11415493 (View on PubMed)

Other Identifiers

MR/N003284/1

Identifier Type: -

Identifier Source: org_study_id