Multiple Screening Methods for the Detection of Chinese Colorectal Advanced Adenomatous Polyps and Cancer
NCT ID: NCT03411707
Last Updated: 2022-05-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
1200 participants
OBSERVATIONAL
2018-03-19
2023-06-30
Brief Summary
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The secondary objective is to compare the performance of these two CRC screening methods to a commercially available FIT assay, both with respect to cancer and advanced adenoma. Lesions will be confirmed as malignant or precancerous by colonoscopy and histopathologic examination.
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Mutiple screening test group
Stool DNA test
Stool DNA test could detect specific gene methylation in stool DNA. Blood mRNA test could detect specific set of gene expression in blood.
Interventions
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Stool DNA test
Stool DNA test could detect specific gene methylation in stool DNA. Blood mRNA test could detect specific set of gene expression in blood.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Subjects haven't received any treatment under colonoscopy within 10 years.
Exclusion Criteria
2. Subjects had the contraindication for colonoscopy.
45 Years
80 Years
ALL
Yes
Sponsors
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Changhai Hospital
OTHER
Tianjin Nankai Hospital
OTHER
Sixth Affiliated Hospital, Sun Yat-sen University
OTHER
Responsible Party
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Hongzhi Zou
Principal investigator
Principal Investigators
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Hongzhi Zou, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
The Sixth Affiliated Hospital, Sun Yet-sen University
Locations
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The Sixth Affiliated Hospital, Sun Yet-sen University
Guangzhou, , China
Changhai Hospital
Shanghai, , China
Tianjin Nankai Hospital
Tianjin, , China
Countries
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Central Contacts
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Facility Contacts
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Ping Lan, MD, PhD
Role: primary
Enda Yu, MBBS
Role: primary
Ximo Wang, MD, PhD
Role: primary
Other Identifiers
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SC2017
Identifier Type: -
Identifier Source: org_study_id
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