Uterine Microbiome in Women with Repeated Implantation Failure and Normal Fertile Women

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

13 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2018-12-31

Brief Summary

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Characterization of the uterine microbiome in women with repeated implantation failure as well as in normal fertile women.

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Detailed Description

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In the midluteal phase of the cycle, a vaginal swab and endometrial biopsy will be obtained.

Conditions

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Repeated Implantation Failure Normal Fertile

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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RIF (women with repeated implantation failure)

Transfer of at least 5 good quality embryos in IVF or ICSI cycles, without achieving pregnancy

Vaginal swab + endometrial biopsy

Intervention Type OTHER

In the midluteal phase of the cycle, a vaginal swab (E swab) and endometrial biopsy (TAO brush) will be obtained.

NF (normal fertile women)

Spontaneous conception or conception after max 9 IUI cycles

Vaginal swab + endometrial biopsy

Intervention Type OTHER

In the midluteal phase of the cycle, a vaginal swab (E swab) and endometrial biopsy (TAO brush) will be obtained.

Interventions

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Vaginal swab + endometrial biopsy

In the midluteal phase of the cycle, a vaginal swab (E swab) and endometrial biopsy (TAO brush) will be obtained.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women between their 18th and 40th birthdays (max 39 years and 364 days at the day of signing the informed consent)
* Able to understand, read and speak Dutch and hence to provide written and oral informed consent
* Negative serological tests for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), Rapid plasma reagin (RPR) for syphilis