BioProtect Balloon Implant™ Balloon System Pivotal Study BP-007

NCT ID: NCT03400150

Last Updated: 2025-02-18

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

222 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-03

Study Completion Date

2021-12-10

Brief Summary

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The BioProtect Balloon Implant™ System is intended to temporarily position the anterior rectal wall away from the prostate during radiotherapy for prostate cancer and in creating this space it is the intent of the balloon to reduce the radiation dose delivered to the anterior rectum. The balloon composed of a biodegradable material that maintains that space for the entire course of prostate radiotherapy treatment and is completely absorbed by the patient's body over time.

Detailed Description

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This study will be a prospective, multi-center, randomized, double-arm, single blind, concurrently controlled study to assess the safety and efficacy of the balloon in prostate cancer subjects undergoing radiotherapy by means of intensity modulation radiation therapy (IMRT).

Conditions

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Prostate Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Subjects will be randomized in a 2:1 ratio (balloon implantation:control)
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants
Study subjects are blinded to group assignment.

Study Groups

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balloon group

Marking + balloon implantation + IMRT

Group Type EXPERIMENTAL

balloon

Intervention Type DEVICE

balloon implantation

Control group

Marking + IMRT

Group Type SHAM_COMPARATOR

Control

Intervention Type OTHER

Control - Marking \& IMRT are standard of care for prostate cancer - there is no study-specific intervention

Interventions

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balloon

balloon implantation

Intervention Type DEVICE

Control

Control - Marking \& IMRT are standard of care for prostate cancer - there is no study-specific intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Be at least 18 years of age
* Have been histologically diagnosed with invasive adenocarcinoma of the prostate, at clinical stage T1-T3 (as determined by a biopsy taken within 9 months of the screening visit)
* Be scheduled for radiation therapy (XRT) by means of IMRT

Exclusion Criteria

* Any prior invasive malignancy (except non-melanomatous skin cancer) unless the subject has been disease free for a minimum of 5 years
* Prior radical prostatectomy
* Prior cryosurgery or radiotherapy for prostate cancer, or other local therapy for prostate cancer
* Prior radiotherapy to the pelvis, including brachytherapy
* History of prior surgery involving the rectum or anus
* Prior surgical procedure involving the peri-rectal and/or peri-prostatic area
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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BioProtect

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Western Radiation Oncology

Apple Valley, California, United States

Site Status

KSK Medical Center

Irvine, California, United States

Site Status

Advanced Urology Institute

Daytona Beach, Florida, United States

Site Status

Rush University Cancer Center

Chicago, Illinois, United States

Site Status

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Baltimore, Maryland, United States

Site Status

Chesapeake Urology Research Associates

Owings Mills, Maryland, United States

Site Status

Urology Nevada

Reno, Nevada, United States

Site Status

Advanced Radiation Center of New York

Lake Success, New York, United States

Site Status

New York University Langone Health

New York, New York, United States

Site Status

Medical University of South Carolina (MUSC)

Charleston, South Carolina, United States

Site Status

Assuta Ashdod

Ashdod, , Israel

Site Status

Rabin Medical Center

Petah Tikva, , Israel

Site Status

Maastro

Maastricht, , Netherlands

Site Status

Institute of Maria Skłodowska-Oncology Centre

Warsaw, , Poland

Site Status

CUF Porto Instituto

Porto, , Portugal

Site Status

Beatson West of Scotland Cancer Centre

Glasgow, , United Kingdom

Site Status

Countries

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United States Israel Netherlands Poland Portugal United Kingdom

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Related Links

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Other Identifiers

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BP-007

Identifier Type: -

Identifier Source: org_study_id

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