The Impact of Non-Alcoholic Fatty Pancreas Disease on Outcome of Acute Pancreatitis

NCT ID: NCT03394378

Last Updated: 2018-01-09

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1662 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-11-06
• Study Completion Date: 2017-12-15

Brief Summary

Obesity is a well-established risk factor for acute pancreatitis (AP). As for non-alcoholic fatty pancreas disease (NAFPD), it is evident that it is correlated with obesity. This is apparently the first study evaluating the association between NAFPD and severity of AP after taking into account several covariates.

Detailed Description

Acute pancreatitis (AP) is a common disease with a highly variable clinical course, which can range from a mild, self-limited disease to severe disease with a mortality rate of 10-20%. It is vital to distinguish severe cases early because they require more aggressive fluid resuscitation and early nutritional support.

Obesity is a well-established risk factor for acute pancreatitis (AP). It leads to ectopic fat accumulation in visceral organs, such as the liver, skeletal muscles, heart and pancreas.

Assuming that attenuation in the pancreas seen on unenhanced computed tomography (CT) scanning is inversely associated with severe outcomes in AP, we investigated the relationship between NAFPD and severity of AP and the significance of pancreas attenuation for the prognosis and mortality in AP patients. The result of this study suggest that decreased pancreas attenuation and P/S ratio are strong predictors of severe pancreatitis, mortality, systemic complication.

Conditions

Non-Alcoholic Fatty Pancreas Disease; Acute Pancreatitis

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

1. diagnosed with AP

2. age>18y

Exclusion Criteria

1. age<18y

2. missing data in the electronic medical record

3. prior attacks of AP

4. without spleen

5. with ambiguous pancreatic margin

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ningbo No. 1 Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Lei Xu, Dr

Role: PRINCIPAL_INVESTIGATOR

Department of gastroenterology,Ningbo No.1 Hospital, Ningbo, China

Locations

Ningbo NO.1 hospital

Ningbo, Zhejiang, China

Countries

China

Other Identifiers

Ningbo3

Identifier Type: -

Identifier Source: org_study_id