The Indigo System in Acute Lower Limb Malperfusion

NCT ID: NCT03386370

Last Updated: 2019-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-01

Study Completion Date

2019-05-31

Brief Summary

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To evaluate, in a controlled setting, the early safety and effectiveness of the Penumbra/Indigo aspiration thrombectomy Systems (San Francisco, California), and to define optimal technique for the use of these systems in patients with confirmed peripheral acute occlusions.

Detailed Description

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Conditions

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Acute Ischemia of Lower Limb

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment by "Indigo" mechanical thrombectomy system

Acute or Chronic clot: if chronic (\> 14 days) no intervention given via Indigo

Group Type OTHER

"Indigo" Mechanical Thrombectomy System

Intervention Type DEVICE

Removal of acute clot (\< 14 days) from the artery causing lower limb ischemia, using the "Indigo" System by Penumbra

Interventions

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"Indigo" Mechanical Thrombectomy System

Removal of acute clot (\< 14 days) from the artery causing lower limb ischemia, using the "Indigo" System by Penumbra

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient presenting with an acute occlusion of lower limb arteries (thrombosis no longer than 14 days)
* Patient presenting a score from I to IIb following Rutherford classification for acute limb ischemia
* Patient is willing to comply with specified follow-up evaluations at the specified times for the duration of the study
* Patient is \>18 years old
* Patient (or their legal representative) understands the nature of the procedure and provides written informed consent, prior to enrolment in the study
* Patient is eligible for treatment with the Indigo System (Penumbra)

Exclusion Criteria

* Estimated time of intraluminal thrombus \> 14 days
* Patients refusing treatment
* Patients for whom antiplatelet therapy, anticoagulants or thrombolytic drugs are contraindicated
* Patients with a history of prior life-threatening contrast medium reaction
* Life expectancy of less than six months
* Any patient considered to be hemodynamically unstable at onset of procedure
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Azienda Ospedaliera Universitaria Senese

OTHER

Sponsor Role lead

Responsible Party

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Carlo Setacci, Gianmarco de Donato

University of Siena

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Vascular Surgery, University of Siena

Siena, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Gianmarco de Donato, MD

Role: CONTACT

+390577585123

Carlo Setacci, MD

Role: CONTACT

+390577233443

Facility Contacts

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Gianmarco de Donato, MD

Role: primary

References

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Yamada R, Adams J, Guimaraes M, Schonholz C. Advantages to Indigo mechanical thrombectomy for ALI: device and technique. J Cardiovasc Surg (Torino). 2015 Jun;56(3):393-400. Epub 2015 Feb 3.

Reference Type BACKGROUND
PMID: 25644826 (View on PubMed)

Other Identifiers

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Indian001

Identifier Type: -

Identifier Source: org_study_id

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