Chronic Total Occlusion Crossing With the Ocelot System - CONNECT II

NCT ID: NCT01537302

Last Updated: 2021-03-22

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-02-29

Study Completion Date

2012-06-30

Brief Summary

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Evaluation of the safety and effectiveness of the Ocelot System to provide OCT-assisted orientation while simultaneously crossing totally occluded femoropopliteal arteries.

Detailed Description

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The purpose of this clinical study is to evaluate the safety and effectiveness of the Ocelot System to provide OCT-assisted orientation while simultaneously crossing chronic total occlusions (CTOs) in femoropopliteal arteries. The Ocelot Catheter is a minimally invasive percutaneous device that is designed to traverse arterial occlusions through the use of spiral wedges contained in the distal tip of the device. The device is also equipped with an OCT (optical coherence tomography) imaging fiber that provides directional orientation and an intravascular view of the vessel wall and target lesion. The Ocelot Catheter is used in conjunction with standard endovascular devices and as an adjunct to fluoroscopic guidance.

Conditions

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Total Atherosclerotic Occlusion of Femoral Artery

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Ocelot System

CTO crossing in femoropopliteal arteries using the Ocelot System

Group Type EXPERIMENTAL

CTO crossing in femoropopliteal arteries CONNECT II

Intervention Type DEVICE

CTO crossing in femoropopliteal arteries using the Ocelot System

Interventions

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CTO crossing in femoropopliteal arteries CONNECT II

CTO crossing in femoropopliteal arteries using the Ocelot System

Intervention Type DEVICE

Other Intervention Names

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Chronic TOtal OcclusioN CrossiNg with thE OCelot SysTem II CONNECT II

Eligibility Criteria

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Inclusion Criteria

* Patient is willing and able to provide informed consent
* Patient is willing and able to comply with the study protocol
* Patient is \> 18 years old
* Patient has peripheral arterial disease requiring revascularization as evidenced by CTA, MRA or angiography
* Patient has an occluded femoropopliteal artery that is 99-100% stenosed and is ≥ 1 cm and ≤ 30 cm in length by visual estimate
* Target vessel is ≥ 3.0 mm in diameter
* Patient has Rutherford Classification of 2-5
* Lesion is recalcitrant to guidewire crossing

Exclusion Criteria

* Patient has a known sensitivity or allergy to contrast materials that cannot be adequately pre-treated
* Patient has a known sensitivity or allergy to aspirin, heparin or anti-platelet medications
* Patient is pregnant or lactating
* Patient has a co-existing disease or medical condition contraindicating percutaneous intervention
* Target vessel is severely calcified as evidenced by angiography
* Target lesion is in a bypass graft
* Target lesion is in a stent (i.e., in-stent restenosis)
* Patient has had a procedure on the target limb within 7 days
* Patient has had a procedure on the target limb within the past 30 days and is unstable
* Patient has a planned surgical or interventional procedure within 30 days after the study procedure
* Patient is simultaneously participating in an investigational device study for treatment of peripheral vascular disease
* Patient has a planned amputation of the target limb
* Patient has a history of bleeding diathesis, coagulopathy or will refuse blood transfusion in cases of emergency
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Avinger, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Matthew Selmon, MD

Role: PRINCIPAL_INVESTIGATOR

Austin Heart Hospital

Arne Schwindt, MD

Role: PRINCIPAL_INVESTIGATOR

Muenster Hospital

Locations

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Arkansas Heart Hospital

Little Rock, Arkansas, United States

Site Status

Sutter Memorial

Sacramento, California, United States

Site Status

Cardiovascular Associates - Alexian Brothers Medical Center

Elk Grove Village, Illinois, United States

Site Status

St. Joseph's Hospital

Fort Wayne, Indiana, United States

Site Status

Detroit Medical Center

Detroit, Michigan, United States

Site Status

St. John Hospital and Medical Center

Detroit, Michigan, United States

Site Status

St. Dominic Hospital

Jackson, Mississippi, United States

Site Status

Deborah Heart and Lung Center

Browns Mills, New Jersey, United States

Site Status

Columbia University Medical Center

New York, New York, United States

Site Status

Jobst Vascular Center

Toledo, Ohio, United States

Site Status

Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, United States

Site Status

Austin Heart

Austin, Texas, United States

Site Status

El Paso Cardiology Associates

El Paso, Texas, United States

Site Status

The Heart Hospital Baylor Plano

Plano, Texas, United States

Site Status

Leipzig Hospital

Leipzig, , Germany

Site Status

Muenster Hospital

Münster, , Germany

Site Status

Mirano Hospital

Mirano, , Italy

Site Status

Countries

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United States Germany Italy

Related Links

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http://www.avinger.com

Avinger web site

Other Identifiers

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AVI OCT 10005

Identifier Type: -

Identifier Source: org_study_id

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