2D Perfusion DSA for the Quantification of Infrapopliteal Angioplasty

NCT ID: NCT04356092

Last Updated: 2020-04-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

7 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-05-02

Study Completion Date

2019-07-14

Brief Summary

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A custom-made, 2D-perfusion digital subtraction angiography (PDSA) algorithm has been designed and implemented towards foot perfusion quantification following endovascular treatment of critical limb ischemia (CLI), in order to assist intra-procedural decision-making and enhance clinical outcomes.

Detailed Description

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This is a prospective, single-center, study investigating the feasibility of 2D-PDSA using newly-developed, non-commercially available, color-coded software for the quantification of foot perfusion following infrapopliteal angioplasty for the treatment of CLI. In total, 7 consecutive patients scheduled to undergo infrapopliteal endovascular treatment of CLI were enrolled. Perfusion Blood Volume (PBV), Mean Transit Time (MTT), and Perfusion Blood Flow (PBF) maps were extracted by analyzing Time-Intensity Curves and signal intensity on the perfused vessel mask. Mean values calculated from user-specified ROIs on perfusion maps were employed to evaluate the patient's pre- and post- endovascular treatment condition.

Conditions

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Ischemia Limb

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

In total, 7 consecutive patients were included in the study. The 2D-perfusion imaging and analysis of the DICOM files were performed after revascularization.
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

2D-perfusion imaging and analysis of the DICOM files was performed after revascularization, by an investigator blinded to the name of the patient or the result of the angioplasty procedure. The participant was also blinded to the results of the perfusion outcomes during follow up.

Study Groups

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Perfusion

Consecutive patients scheduled to undergo infrapopliteal angioplasty or stenting, or both, as part of their standard treatment for Rutherford-Becker class 5 and 6 chronic limb-threatening ischemia, were included in the study. All procedures were performed using local anesthesia. An antegrade access was used in all patients followed by the deployment of a 5 or 6 Fr arterial sheaths. A semi-lateral foot projection was preferred and the pre-revascularization DSA of the foot was performed via a 5 Fr angiographic catheter placed at the distal third of the popliteal artery. Following revascularization of one or more tibial arteries, the catheter was placed at the same popliteal segment and post-procedural DSA of the foot was performed following the exact pre-revascularization injection protocol at the same semi-lateral projection. The 2D-perfusion imaging and analysis of the DICOM files was performed after revascularization.

Group Type EXPERIMENTAL

2D perfusion digital subtraction angiography of the foot.

Intervention Type DIAGNOSTIC_TEST

2D perfusion digital subtraction angiography of the foot was performed after infrapopliteal angioplasty and Perfusion Blood Volume (PBV), Mean Transit Time (MTT), and Perfusion Blood Flow (PBF) maps were extracted by analyzing Time-Intensity Curves and signal intensity on the perfused vessel mask.

Interventions

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2D perfusion digital subtraction angiography of the foot.

2D perfusion digital subtraction angiography of the foot was performed after infrapopliteal angioplasty and Perfusion Blood Volume (PBV), Mean Transit Time (MTT), and Perfusion Blood Flow (PBF) maps were extracted by analyzing Time-Intensity Curves and signal intensity on the perfused vessel mask.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Infrapopliteal angioplasty

Eligibility Criteria

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Inclusion Criteria

* Patients prescheduled for infrapopliteal angioplasty due to chronic limb-threatening ischemia.
* Written informed consent obtained

Exclusion Criteria

* Image post-processing not feasible due to significant motion artifacts produced during DSA
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital of Patras

OTHER

Sponsor Role collaborator

Attikon Hospital

OTHER

Sponsor Role lead

Responsible Party

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Stavros Spiliopoulos

Assistant Professor in Interventional Radiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dimitris Karnamatidis, MD, PhD

Role: STUDY_CHAIR

Patras University Hospital, Rion, Greece

George Kagadis, PhD, FAAPM

Role: PRINCIPAL_INVESTIGATOR

University of Patras, Greece

Locations

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Patras University Hospital

Pátrai, Achaia, Greece

Site Status

Countries

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Greece

References

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Kagadis GC, Tsantis S, Gatos I, Spiliopoulos S, Katsanos K, Karnabatidis D. 2D perfusion DSA with an open-source, semi-automated, color-coded software for the quantification of foot perfusion following infrapopliteal angioplasty: a feasibility study. Eur Radiol Exp. 2020 Sep 2;4(1):47. doi: 10.1186/s41747-020-00176-z.

Reference Type DERIVED
PMID: 32875390 (View on PubMed)

Other Identifiers

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264/12.04.2017

Identifier Type: -

Identifier Source: org_study_id

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