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Target Therapies Resistance Molecular Profiling in Patients With Neoplastic Disease

NCT ID: NCT03347318

Last Updated: 2017-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

2500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-31

Study Completion Date

2021-12-31

Brief Summary

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The main purpose of this study is to define the molecular profile of selected solid tumors. From each participants will be collected biological materials for molecular analysis, including saliva, blood and vital tumor tissue derived form surgical or biopsy procedures. Whereas possible, vital tumor specimens will be inoculated and propagated in immunocompromised NOD/SCID mice to study the genetic correlations between genetic status and response to target drugs.

Detailed Description

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Conditions

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Solid Tumors

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

Patients with at least one of the following selected solid tumors:

* Colorectal Cancer (primary or with synchronous/metachronous liver metastases)
* Prostate Cancer
* Head \& Neck Tumors
* Gastric Cancer
* Glioblastoma
* Breast Cancer
* Hepatocarcinoma
* Biliary Tract Carcinoma
* Lung Cancer (primary)
* Rare Tumors (incidence ≤ 5x10-6)
* Metastatic Sarcoma
* Metastatic Melanoma

Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondazione del Piemonte per l'Oncologia

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ospedale Regionale Umberto Parini

Aosta, , Italy

Site Status RECRUITING

Policlinico S.Orsola Malpighi

Bologna, , Italy

Site Status RECRUITING

Istituto Di Candiolo - Fondazione Del Piemonte Per L'Oncologia (FPO-Irccs)

Candiolo, , Italy

Site Status RECRUITING

Azienda Ospedaliero-Universitaria Careggi

Genova, , Italy

Site Status RECRUITING

Azienda Ospedaliera Niguarda Ca'Granda

Milan, , Italy

Site Status RECRUITING

IEO - Istiuto Europeo di Oncologia

Milan, , Italy

Site Status RECRUITING

Fondazione IRCCS - Istituto Nazionale dei Tumori

Milan, , Italy

Site Status RECRUITING

AOU S. Luigi Gonzaga

Orbassano, , Italy

Site Status RECRUITING

IOV - Istituto Oncologico Veneto

Padua, , Italy

Site Status RECRUITING

Azienda Ospedaliero Universitaria Pisana

Pisa, , Italy

Site Status RECRUITING

Policlinico Universitario Campus Biomedico

Roma, , Italy

Site Status RECRUITING

A.O. Città della Salute e della Scienza di Torino - Presidio ospedaliero Ostetrico Ginecologico Sant'Anna

Turin, , Italy

Site Status RECRUITING

AOU Città della Salute e della Scienza di Torino - Presidio Molinette

Turin, , Italy

Site Status RECRUITING

Ospedale Mauriziano Umberto I

Turin, , Italy

Site Status RECRUITING

Presidio Ospedaliero Martini

Turin, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Silvia Marsoni, MD

Role: CONTACT

Email: [email protected]

Facility Contacts

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Antonio Trogu, MD

Role: primary

Andrea Ardizzoni, MD

Role: primary

Silvia Marsoni, MD

Role: primary

Enrico Mini, MD

Role: primary

Salvatore Siena, MD

Role: primary

Giuseppe Curigliano, MD

Role: primary

Filippo De Braud, MD

Role: primary

Silvia Novello, MD

Role: primary

Vittorina Zagonel, MD

Role: primary

Alfredo Falcone, MD

Role: primary

Giuseppe Tonini, MD

Role: primary

Gianluca Gregori, MD

Role: primary

Paola Cassoni, MD

Role: primary

Alessandro Ferrero, MD

Role: primary

Erika Crosetti, MD

Role: primary

Other Identifiers

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001-IRCC-00IIS-10

Identifier Type: -

Identifier Source: org_study_id