Endurant CHevAr New Indication Trial: ENCHANT

NCT ID: NCT03320252

Last Updated: 2025-09-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-10-26

Study Completion Date

2030-07-31

Brief Summary

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The purpose of the post-market study is to assess the clinical outcomes, safety, and performance of the Endurant Chimney Graft Technique (Endurant Stent Graft Systems used with a balloon-expandable covered stent graft) for treatment of juxtarenal aortic aneurysms with a short infrarenal neck in a real world setting.

Detailed Description

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Conditions

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AAA - Abdominal Aortic Aneurysm

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Endurant Chimney Graft Technique

Medtronic Endurant II and Endurant IIs Stent Graft Systems and balloon-expandable covered stent graft systems approved for use in the renal arteries. These devices will be utilized in a chimney graft configuration.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject is ≥18 years old
* Subject is scheduled for primary treatment of the juxtarenal aortic aneurysm with a short infrarenal neck (i.e. no revision subjects)
* Subject is able and willing to comply with the protocol and to adhere to the follow-up requirements
* Subject has provided written informed consent
* Subject is an eligible candidate according to the currently available Endurant II/IIs instructions for use for ChEVAR
* Subject has a juxtarenal aortic aneurysm with a short infrarenal neck (definition of juxtarenal aortic aneurysm with a short infrarenal neck will be in accordance with commercially available Endurant II/IIs instructions for use for ChEVAR).

Exclusion Criteria

* Subject is participating in a concurrent study which may confound study results
* Subject has a life expectancy ≤ 2 year
* Subject has an aneurysm that is:

* Suprarenal or pararenal
* Isolated iliofemoral
* Mycotic
* Inflammatory
* Pseudoaneurysm
* Subject requires emergent aneurysm treatment, for example, trauma or rupture
* Subject has previously undergone surgical treatment for abdominal aortic aneurysm
* Subject is a female of childbearing potential in whom pregnancy cannot be excluded
* Subject has a known hypersensitivity or contraindication to anticoagulants, anti-platelets, or contrast media, which is not amenable to pre-treatment
* Subject has a creatinine level \>2.0 mg/dl (or \>176.8 μmol/L) and/or is on dialysis
* Subject has an active COVID-19 infection or relevant history of COVID-19. Relevant history of COVID-19 is defined as availability of a positive COVID-19 test with sequela or hospitalization for treatment of COVID-19. Subjects with a positive COVID-19 test who were asymptomatic or had mild symptoms should be excluded only if the positive test was less than 6 months prior to enrollment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic Cardiovascular

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ordensklinikum Linz GmbH / Elisabethinen

Linz, , Austria

Site Status

CHU de Bordeaux - Centre Universitaire Pellegrin

Bordeaux, , France

Site Status

Hôpitaux Universitaires Paris Ile-de-France Ouest - Hôpital Ambroise-Paré

Boulogne-Billancourt, , France

Site Status

Klinikum Chemnitz gGmbH

Chemnitz, , Germany

Site Status

Elisabeth Krankenhaus Essen GmbH

Essen, , Germany

Site Status

Universitäts Klinikum Frankfurt - Goethe-Universität

Frankfurt am Main, , Germany

Site Status

Universitätsklinikum Heidelberg

Heidelberg, , Germany

Site Status

St. Franziskus-Hospital Münster GmbH

Münster, , Germany

Site Status

Evaggelismos General Hospital of Athens

Athens, , Greece

Site Status

University Hospital of Larissa

Larissa, , Greece

Site Status

Ippokrateio General Hospital of Thessaloniki

Thessaloniki, , Greece

Site Status

Azienda Ospedaliera di Cosenza

Cosenza, , Italy

Site Status

Ospedale Civile Sant'Andrea

La Spezia, , Italy

Site Status

Azienda Ospedaliera San Camillo Forlanini - Ospedale San Camillo

Roma, , Italy

Site Status

Stichting Rijnstate Ziekenhuis

Arnhem, , Netherlands

Site Status

Medisch Spectrum Twente

Enschede, , Netherlands

Site Status

Zuyderland Medisch Centrum

Heerlen, , Netherlands

Site Status

Hospital de Santa Marta

Lisbon, , Portugal

Site Status

Russian Cardiologic Research and Production Complex, Russian Ministry of Health

Moscow, , Russia

Site Status

CINRE s.r.o.

Bratislava, , Slovakia

Site Status

Hospital Clinic de Barcelona

Barcelona, , Spain

Site Status

Corporacío Parc Taulí - Hospital de Sabadell

Sabadell, , Spain

Site Status

Skånes Universitetssjukhus Malmö

Malmo, , Sweden

Site Status

Centre Hospitalier Universitaire Vaudois (CHUV)

Lausanne, , Switzerland

Site Status

St George's University Hospitals - NHS Trust

London, , United Kingdom

Site Status

Central Manchester University Hospitals NHS - Manchester Royal Infirmary

Manchester, , United Kingdom

Site Status

Countries

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Austria France Germany Greece Italy Netherlands Portugal Russia Slovakia Spain Sweden Switzerland United Kingdom

Other Identifiers

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MDT16022

Identifier Type: -

Identifier Source: org_study_id

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