Endurant Stent Graft Natural Selection Global Postmarket Registry

NCT ID: NCT00870051

Last Updated: 2022-02-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1266 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-04-08

Study Completion Date

2021-09-23

Brief Summary

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The purpose of ENGAGE is to prospectively collect global 'real world' data on the Endurant Stent Graft System from AAA subjects.

Detailed Description

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The Endurant Stent Graft Natural Selection Global Post-market Registry, ENGAGE is initiated to expand the clinical knowledge base by including 'real world' subjects, applying a minimal amount of subject selection criteria. This subject group may better represent the subject profile treated in actual clinical practice without selecting sub-groups of particular low/high risk or excluding certain diseases. ENGAGE aims at following and documenting the subject selections, diagnostic tools used and treatment interventions chosen by the vascular surgeon or interventional radiologist. ENGAGE will not impose CIP required study procedures affecting clinical practice.

Conditions

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Aortic Aneurysm, Abdominal

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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AAA patients

Subjects diagnosed with an AAA who are considered candidates for endovascular repair with Endurant Stent Graft, and who meet the inclusion/exclusion criteria are intended to participate in this registry

Endurant Stent Graft

Intervention Type DEVICE

Endurant Stent Graft implantation

Interventions

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Endurant Stent Graft

Endurant Stent Graft implantation

Intervention Type DEVICE

Other Intervention Names

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EVAR

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years or minimum age as required by local regulations
* Indication for elective surgical repair of AAA with an endovascular stent graft in accordance with the applicable guidelines on endovascular interventions and the Instructions for Use of the Endurant Stent Graft System
* Signed consent form ("Patient informed consent Form" or "Patient Data Release Authorization Form"). The subject or legal representative has been informed of the nature of the trial and has consented to participate and authorized the collection and release of his medical information
* Intention to electively implant the ENDURANT Stent Graft System
* Ability and willingness to comply with the CIP.

Exclusion Criteria

* High probability of non-adherence to physician's follow-up requirements
* Current participation in a concurrent trial which may confound study results
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic Cardiovascular

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Vicente Riambau, Prof.

Role: STUDY_DIRECTOR

Hospital Clinic of Barcelona

Furuzan Numan, prof

Role: STUDY_DIRECTOR

Memorial Hospital Istanbul

Robert A. Fitridge, Dr.

Role: STUDY_DIRECTOR

The Queen Elizabeth Hospital, Woodville, South Adelaide, Australia

Yehuda Wolf, Prof.

Role: STUDY_DIRECTOR

Tel Aviv Sourasky Medical Center, Israel

Dittmar Böckler, Prof.

Role: STUDY_DIRECTOR

Universtiy of Heidelberg, Germany

Paul Hayes, Dr.

Role: STUDY_DIRECTOR

Addenbrookes Hospital, Cambridge, Great Britain

Locations

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Hospital Italiano de Buenos Aires

Buenos Aires, , Argentina

Site Status

Clínica La Sagrada Familia

Buenos Aires, , Argentina

Site Status

Royal Prince Alfred Hospital

Camperdown, New South Wales, Australia

Site Status

Royal Brisbane and Women's Hospital

Brisbane, Queensland, Australia

Site Status

St Andrew's Hospital

Adelaide, South Australia, Australia

Site Status

The Queen Elizabeth Hospital

Adelaide, South Australia, Australia

Site Status

Box Hill Hospital

Melbourne, Victoria, Australia

Site Status

Epworth Healthcare - Epworth Eastern

Melbourne, Victoria, Australia

Site Status

JMLS Medical Services PTY, trading as Perth Institute of Vascular Research

Nedlands, Western Australia, Australia

Site Status

Royal Perth Hospital

Perth, Western Australia, Australia

Site Status

Hollywood Private Hospital

Perth, Western Australia, Australia

Site Status

Krankenhaus Hietzing

Vienna, , Austria

Site Status

Imeldaziekenhuis

Bonheiden, , Belgium

Site Status

AZ Sint-Blasius-Campus Dendermonde

Dendermonde, , Belgium

Site Status

Universitair Ziekenhuis Antwerpen

Edegem, , Belgium

Site Status

Universitair Ziekenhuis Gent

Ghent, , Belgium

Site Status

Queen Elizabeth II Health Sciences Centre

Halifax, , Canada

Site Status

London Health Sciences Centre - Victoria Hospital

London, , Canada

Site Status

Glen Royal Victoria Hospital

Montreal, , Canada

Site Status

CHUQ - Hôpital Saint-François d'Assise

Québec, , Canada

Site Status

Toronto General Hospital

Toronto, , Canada

Site Status

Chinese PLA General Hospital

Beijing, , China

Site Status

West China Hospital of Sichuan University

Chengdu, , China

Site Status

People's Hospital of Guangdong Province

Guangzhou, , China

Site Status

Fundacion Cardioinfantil

Bogotá, , Colombia

Site Status

IKEM - Institutu Klinicke a Experimentalni Mediciny

Prague, , Czechia

Site Status

CHU de Bordeaux - Centre Universitaire Pellegrin

Bordeaux, , France

Site Status

Hôpitaux Universitaires - Hôpital Henri Mondor

Créteil, , France

Site Status

Hôpital Haut-Lévêque - CHU de Bordeaux

Pessac, , France

Site Status

Universitätsklinikum Heidelberg

Heidelberg, , Germany

Site Status

St. Franziskus-Hospital Münster GmbH

Münster, , Germany

Site Status

Städtisches Klinikum Solingen

Solingen, , Germany

Site Status

Euromedica - Kyanous Stavros General Hospital

Thessaloniki, , Greece

Site Status

Papageorgiou General Hospital

Thessaloniki, , Greece

Site Status

Queen Mary Hospital

Hong Kong, , Hong Kong

Site Status

Tel Aviv Sourasky Medical Center

Tel Aviv, , Israel

Site Status

Policlinico Sant' Orsola - Malpighi

Bologna, , Italy

Site Status

Azienda Ospedaliera-Universitaria Careggi

Florence, , Italy

Site Status

Azienda Ospedaliera Universitaria Senese

Siena, , Italy

Site Status

Vilnius University Hospital Santaros Klinikos

Vilnius, , Lithuania

Site Status

Rijnstate - Locatie Arnhem

Arnhem, , Netherlands

Site Status

Catharina Ziekenhuis

Eindhoven, , Netherlands

Site Status

Zuyderland Medisch Centrum Heerlen

Heerlen, , Netherlands

Site Status

St. Antonius Ziekenhuis

Nieuwegein, , Netherlands

Site Status

Erasmus Medisch Centrum

Rotterdam, , Netherlands

Site Status

Sint-Elisabeth Ziekenhuis

Tilburg, , Netherlands

Site Status

Auckland City Hospital

Auckland, , New Zealand

Site Status

Waikato District Health Board

Hamilton, , New Zealand

Site Status

Helse Bergen HF - Haukeland Universitetssjukehus

Bergen, , Norway

Site Status

Oslo Universitetssykehus-Rikshospitalet

Oslo, , Norway

Site Status

Universitetssykehuset Nord-Norge

Tromsø, , Norway

Site Status

Samodzielny Publiczny Szpital Kliniczny Nr 2 PUM w Szczecinie

Szczecin, , Poland

Site Status

Szpital Bielanski

Warsaw, , Poland

Site Status

Hospital de Santa Maria-Centro Hospitalar Lisboa Norte, EPE

Lisbon, , Portugal

Site Status

Narodny ustav srdcovych a cievnych chorob, a.s. (NUSCH)

Bratislava, , Slovakia

Site Status

Life Healthcare - Life Kingsbury Hospital

Cape Town, , South Africa

Site Status

Life Healthcare - Life St Georges Hospital

Port Elizabeth, , South Africa

Site Status

Netcare Unitas Hospital

Pretoria, , South Africa

Site Status

Chonnam National University Hospital

Gwangju, , South Korea

Site Status

Yonsei University health System -Severence Hospital

Seoul, , South Korea

Site Status

Hospital Universitari Clínic de Barcelona

Barcelona, , Spain

Site Status

Complejo Hospitalario Universitario Granada Hospital Campus de la Salud

Granada, , Spain

Site Status

Hospital Universitario Central de Asturias

Oviedo, , Spain

Site Status

Hospital Universitario Dr. Peset

Valencia, , Spain

Site Status

Hospital Clínico Universitario de Valladolid

Valladolid, , Spain

Site Status

Sahlgrenska Universitetssjukhuset

Gothenburg, , Sweden

Site Status

Universitetssjukhuset Örebro

Örebro, , Sweden

Site Status

Södersjukhuset

Stockholm, , Sweden

Site Status

Inselspital - Universitätsspital Bern

Bern, , Switzerland

Site Status

Songklanagarind Hospital

Songkhla, , Thailand

Site Status

Istanbul Universitesi - Istanbul Tip Fakultesi Hastanesi

Istanbul, , Turkey (Türkiye)

Site Status

Memorial Sisli Hastanesi

Istanbul, , Turkey (Türkiye)

Site Status

Dokuz Eylül University

Izmir, , Turkey (Türkiye)

Site Status

Adana Baskent University Hospital

Yüreğir, , Turkey (Türkiye)

Site Status

Cambridge University Hospitals NHS Foundation Trust - Addenbrooke's Hospital

Cambridge, , United Kingdom

Site Status

The Royal Liverpool and NHS Broadgreen University Hospitals - Royal Liverpool University Hospital

Liverpool, , United Kingdom

Site Status

St George's University Hospitals - NHS Trust

London, , United Kingdom

Site Status

Wythenshawe Hospital

Manchester, , United Kingdom

Site Status

The Newcastle upon Tyne Hospitals NHS Foundation Trust - Freeman Hospital

Newcastle upon Tyne, , United Kingdom

Site Status

Institucion Medica Uruguaya

Montevideo, , Uruguay

Site Status

Countries

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Argentina Australia Austria Belgium Canada China Colombia Czechia France Germany Greece Hong Kong Israel Italy Lithuania Netherlands New Zealand Norway Poland Portugal Slovakia South Africa South Korea Spain Sweden Switzerland Thailand Turkey (Türkiye) United Kingdom Uruguay

References

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Bockler D, Fitridge R, Wolf Y, Hayes P, Silveira PG, Numan F, Riambau V; ENGAGE Investigators. Rationale and design of the Endurant Stent Graft Natural Selection Global Postmarket Registry (ENGAGE): interim analysis at 30 days of the first 180 patients enrolled. J Cardiovasc Surg (Torino). 2010 Aug;51(4):481-91.

Reference Type RESULT
PMID: 20671632 (View on PubMed)

Stokmans RA, Teijink JA, Forbes TL, Bockler D, Peeters PJ, Riambau V, Hayes PD, van Sambeek MR. Early results from the ENGAGE registry: real-world performance of the Endurant Stent Graft for endovascular AAA repair in 1262 patients. Eur J Vasc Endovasc Surg. 2012 Oct;44(4):369-75. doi: 10.1016/j.ejvs.2012.07.005. Epub 2012 Jul 24.

Reference Type RESULT
PMID: 22835762 (View on PubMed)

Stokmans RA, Teijink JA, Cuypers PW, Riambau V, van Sambeek MR. No differences in perioperative outcome between symptomatic and asymptomatic AAAs after EVAR: an analysis from the ENGAGE Registry. Eur J Vasc Endovasc Surg. 2012 Jun;43(6):667-73. doi: 10.1016/j.ejvs.2012.02.034. Epub 2012 Mar 21.

Reference Type RESULT
PMID: 22440235 (View on PubMed)

Dubois L, Novick TV, Harris JR, Derose G, Forbes TL. Outcomes after endovascular abdominal aortic aneurysm repair are equivalent between genders despite anatomic differences in women. J Vasc Surg. 2013 Feb;57(2):382-389.e1. doi: 10.1016/j.jvs.2012.09.075. Epub 2012 Dec 21.

Reference Type RESULT
PMID: 23266281 (View on PubMed)

Pol RA, Zeebregts CJ, van Sterkenburg SM, Reijnen MM; ENGAGE Investigators. Thirty-day outcome and quality of life after endovascular abdominal aortic aneurysm repair in octogenarians based on the Endurant Stent Graft Natural Selection Global Postmarket Registry (ENGAGE). J Vasc Surg. 2012 Jul;56(1):27-35. doi: 10.1016/j.jvs.2011.12.080. Epub 2012 Mar 28.

Reference Type RESULT
PMID: 22459746 (View on PubMed)

Tang T, Sadat U, Walsh S, Hayes PD; ENGAGE Investigators. Comparison of the endurant bifurcated endograft vs. aortouni-iliac stent-grafting in patients with abdominal aortic aneurysms: experience from the ENGAGE registry. J Endovasc Ther. 2013 Apr;20(2):172-81. doi: 10.1583/1545-1550-20.2.172.

Reference Type RESULT
PMID: 23581758 (View on PubMed)

Pol RA, Zeebregts CJ, van Sterkenburg SM, Ferreira LM, Goktay Y, Reijnen MM; Endurant Stent Graft Natural Selection Global Postmarket Registry (ENGAGE) Investigators. Outcome and quality of life after endovascular abdominal aortic aneurysm repair in octogenarians. J Vasc Surg. 2014 Aug;60(2):308-17. doi: 10.1016/j.jvs.2014.02.009. Epub 2014 Mar 20.

Reference Type RESULT
PMID: 24657065 (View on PubMed)

Kiguchi MM, Forbes TL, Teijink JA, Pliagas GA, Ellozy SH, Bockler D, Makaroun MS. Clinical application and early outcomes of the aortouni-iliac configuration for endovascular aneurysm repair. J Vasc Surg. 2014 Dec;60(6):1452-9. doi: 10.1016/j.jvs.2014.08.063. Epub 2014 Oct 3.

Reference Type RESULT
PMID: 25282698 (View on PubMed)

Faure EM, Becquemin JP, Cochennec F; ENGAGE collaborators. Predictive factors for limb occlusions after endovascular aneurysm repair. J Vasc Surg. 2015 May;61(5):1138-45.e2. doi: 10.1016/j.jvs.2014.11.084. Epub 2015 Feb 2.

Reference Type RESULT
PMID: 25656594 (View on PubMed)

Dijkstra ML, Zeebregts CJ, Verhagen HJM, Teijink JAW, Power AH, Bockler D, Peeters P, Riambau V, Becquemin JP, Reijnen MMPJ; ENGAGE investigators. Incidence, natural course, and outcome of type II endoleaks in infrarenal endovascular aneurysm repair based on the ENGAGE registry data. J Vasc Surg. 2020 Mar;71(3):780-789. doi: 10.1016/j.jvs.2019.04.486. Epub 2019 Aug 20.

Reference Type DERIVED
PMID: 31443976 (View on PubMed)

Dijkstra ML, van Sterkenburg SM, Lardenoye JW, Zeebregts CJ, Reijnen MM; ENGAGE Investigators. One-Year Outcomes of Endovascular Aneurysm Repair in High-Risk Patients Using the Endurant Stent-Graft: Comparison of the ASA Classification and SVS/AAVS Medical Comorbidity Grading System for the Prediction of Mortality and Adverse Events. J Endovasc Ther. 2016 Aug;23(4):574-82. doi: 10.1177/1526602816648455. Epub 2016 May 10.

Reference Type DERIVED
PMID: 27170150 (View on PubMed)

Broos PP, Stokmans RA, van Sterkenburg SM, Torsello G, Vermassen F, Cuypers PW, van Sambeek MR, Teijink JA. Performance of the Endurant stent graft in challenging anatomy. J Vasc Surg. 2015 Aug;62(2):312-8. doi: 10.1016/j.jvs.2015.03.024. Epub 2015 May 1.

Reference Type DERIVED
PMID: 25937606 (View on PubMed)

Other Identifiers

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P#888

Identifier Type: -

Identifier Source: org_study_id

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