The Effects of Mood on Cerebral Perfusion

NCT ID: NCT03302130

Last Updated: 2022-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-08

Study Completion Date

2017-11-17

Brief Summary

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Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the effects of a different mood state (neutral, positive and negative mood), induced using subjects own memories, on both global and regional cerebral perfusion, measured with arterial spin labeling.

Detailed Description

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Conditions

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Cerebral Perfusion

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Imaging healthy volunteers

Mood induction: positive, negative, neutral mood (using subjects own memories) Arterial spin labeling MRI Physiological monitoring

Group Type EXPERIMENTAL

Mood induction (using own memories)

Intervention Type BEHAVIORAL

Subjects deliver three positive, three negative and three neutral memories 30 seconds reliving a memory - answering questions about the memory - reliving memory for 2 minutes during ASL-MRI

Arterial spin labeling MRI

Intervention Type DEVICE

Single PLD PCASL

Physiological monitoring

Intervention Type DEVICE

During MRI: heart rate, end-tidal CO2, respiratory rate and skin conductance

Interventions

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Mood induction (using own memories)

Subjects deliver three positive, three negative and three neutral memories 30 seconds reliving a memory - answering questions about the memory - reliving memory for 2 minutes during ASL-MRI

Intervention Type BEHAVIORAL

Arterial spin labeling MRI

Single PLD PCASL

Intervention Type DEVICE

Physiological monitoring

During MRI: heart rate, end-tidal CO2, respiratory rate and skin conductance

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Healthy university students
* between 18 and 30 years old

Exclusion Criteria

* No informed consent
* Not using hormonal contraception
* MRI-contraindications
* Claustrophobia
* Pregnancy
* Chronic diseases and chronic medication use
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Ghent

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eric Achten, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Ghent

Other Identifiers

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EC/2015/0528

Identifier Type: -

Identifier Source: org_study_id

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