Effectiveness Study of New Generation Bednets in the Context of Conventional Insecticide Resistance in the Democratic Republic of the Congo

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

1680 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-02

Study Completion Date

2019-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Despite the mass distribution of LLINs (long-lasting insecticidal nets) as a Malaria control strategy, populations are still continuously exposed to a high frequency of malarial inoculation in some countries. The situation can be explained by a swift increase in the resistance of Anopheles to common insecticides. To preserve the gains of insecticides and improve their effectiveness, a new generation of bednets treated with piperonyl butoxide combination insectides have emerged.But more evidence is needed to plead for scale up of their usage. The lack of information relating to the additional impact of that combination on the transmission of Malaria, its relative efficacy in real-life setting and its safety in users are the rationale for more investigation.This will be a randomized controlled study on a dynamic cohort of households with 1680, 0-10 years-old subjects in 30 villages will be recruited to compute the effectiveness of this new tool.

The findings will be useful information for decision-making by national malaria control programs, their partners, the international community and the bednet manufacturers with regard to the effectiveness of the new combination of insecticides in real-life context. The results will also enable a better design of the tool in the future and a broader understanding of long-term dynamics for sustainability, as well as identification of some factors with negative impacts on the benefits of the strategy.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Rwanda

NCT04230161

Malaria

COMPLETED

Evaluation of Insecticide Treated Nets and Wall Liners for the Prevention of Malaria

NCT01043796

Malaria

COMPLETED PHASE3

Efficacy of Two Dual Active Ingredient Long Lasting Insecticidal Nets for Control of Malaria Transmitted by Pyrethroid Resistant Vectors in Benin

NCT03931473

Malaria Anemia

COMPLETED NA

Efficacy of Three Novel Bi-treated Long Lasting Insecticidal Nets

NCT03554616

Malaria Anaemia

COMPLETED NA

Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Mozambique

NCT04716387

Malaria

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Insecticide Resistance

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Cluster-randomized trial

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

The 2 groups of villages will randomly receive either the bednets treated with conventional insecticide (Pyrethroid) or the synergistic combination of insecticides. None of the groups knows which bednets they receive.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Control

The arm will receive bednets treated with conventional insecticide (Pyrethroid)

Group Type ACTIVE_COMPARATOR

Pyrethroids

Intervention Type DRUG

Conventional insecticide

Experimental

The arm will receive bednets treated with new generation of insecticides (synergistic combination of insecticides)

Group Type EXPERIMENTAL

synergistic combination of insecticides

Intervention Type DRUG

third generation insecticide -treated bednets

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

synergistic combination of insecticides

third generation insecticide -treated bednets

Intervention Type DRUG

Pyrethroids

Conventional insecticide

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Ability and willingness of the head of the household to participate based on signed informed consent (or fingerprint) and with the assistance of an impartial witness (if the head of the household is illiterate)