The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention

NCT ID: NCT01697852

Last Updated: 2012-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

22300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2012-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study is a cluster randomised trial to compare the effectiveness of indoor residual spraying (IRS) combined with the use of long lasting insecticidal nets (LLINs) with the effectiveness of LLINs alone for preventing malaria infection and morbidity. The primary outcome measure is prevalence of parasitaemia and anaemia in children aged 0.5-10 years, measured in cross sectional surveys. Secondary outcomes include relative population density for each mosquito vector species, malaria transmission as measured by entomological inoculation rates (EIR) by mosquito vector species, monitoring of resistance markers including kdr, and user acceptability of LLINs compared with IRS.

Findings from this study are expected to inform decision making so that resource utilization can be optimised.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Malaria

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

vector control LLIN IRS

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

LLIN plus IRS

LLIN by universal coverage campaign 2 rounds of indoor residual spraying with bendiocarb insecticide

Group Type EXPERIMENTAL

Indoor residual spraying with bendiocarb

Intervention Type OTHER

2 rounds of indoor residual spraying with bendiocarb insecticide, 4 months apart

LLIN by universal coverage campaign

Intervention Type OTHER

Long lasting Insecticide treated mosquito net

LLIN only

LLIN by universal coverage campaign

Group Type ACTIVE_COMPARATOR

LLIN by universal coverage campaign

Intervention Type OTHER

Long lasting Insecticide treated mosquito net

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Indoor residual spraying with bendiocarb

2 rounds of indoor residual spraying with bendiocarb insecticide, 4 months apart

Intervention Type OTHER

LLIN by universal coverage campaign

Long lasting Insecticide treated mosquito net

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Ficam Olyset nets

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* resident in selected cluster (village)

Exclusion Criteria

* Not resident in selected cluster (village)
Minimum Eligible Age

6 Months

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

National Institute for Medical Research, Tanzania

OTHER_GOV

Sponsor Role collaborator

Kilimanjaro Christian Medical Centre, Tanzania

OTHER

Sponsor Role collaborator

London School of Hygiene and Tropical Medicine

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Mark Rowland, PHD

Role: PRINCIPAL_INVESTIGATOR

London School of Hygiene and Tropical Medicine

Immo Kleinschmidt, PHD

Role: PRINCIPAL_INVESTIGATOR

London School of Hygiene and Tropical Medicine

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

PAMVERC office

Muleba, Kagera, Tanzania

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Tanzania

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Mark Rowland, PHD

Role: CONTACT

Email: [email protected]

Immo Kleinschmidt, PHD

Role: CONTACT

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Natacha Protopopoff, PHD

Role: primary

References

Explore related publications, articles, or registry entries linked to this study.

Kleinschmidt I, Schwabe C, Shiva M, Segura JL, Sima V, Mabunda SJ, Coleman M. Combining indoor residual spraying and insecticide-treated net interventions. Am J Trop Med Hyg. 2009 Sep;81(3):519-24.

Reference Type BACKGROUND
PMID: 19706925 (View on PubMed)

West PA, Protopopoff N, Rowland MW, Kirby MJ, Oxborough RM, Mosha FW, Malima R, Kleinschmidt I. Evaluation of a national universal coverage campaign of long-lasting insecticidal nets in a rural district in north-west Tanzania. Malar J. 2012 Aug 10;11:273. doi: 10.1186/1475-2875-11-273.

Reference Type RESULT
PMID: 22882836 (View on PubMed)

West PA, Protopopoff N, Wright A, Kivaju Z, Tigererwa R, Mosha FW, Kisinza W, Rowland M, Kleinschmidt I. Enhanced protection against malaria by indoor residual spraying in addition to insecticide treated nets: is it dependent on transmission intensity or net usage? PLoS One. 2015 Mar 26;10(3):e0115661. doi: 10.1371/journal.pone.0115661. eCollection 2015.

Reference Type DERIVED
PMID: 25811379 (View on PubMed)

West PA, Protopopoff N, Wright A, Kivaju Z, Tigererwa R, Mosha FW, Kisinza W, Rowland M, Kleinschmidt I. Indoor residual spraying in combination with insecticide-treated nets compared to insecticide-treated nets alone for protection against malaria: a cluster randomised trial in Tanzania. PLoS Med. 2014 Apr 15;11(4):e1001630. doi: 10.1371/journal.pmed.1001630. eCollection 2014 Apr.

Reference Type DERIVED
PMID: 24736370 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

ITDCVP54

Identifier Type: -

Identifier Source: org_study_id