Brain Markers of Suicide Risk and Psychological Pain in Elderly Depressed Patients

NCT ID: NCT03287986

Last Updated: 2020-03-09

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-08-18
• Study Completion Date: 2019-12-13

Brief Summary

The main objective of this study is to show MRI functional and structural differences between depressed elderly patients with a history of attempted suicide compared to depressed elderly patients with no history of attempted suicide and to elderly subjects with no personal history of depression or attempted suicide (healthy controls).

Conditions

Depressive Disorder; Suicide, Attempted

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Suicide attempters

Depressed patients over 60 years of age with a personal history of suicide attempts scanned with MRI

MRI

Intervention Type: OTHER

Structural and functional sequences

Patient controls

depressed patients over 60 years of age without a personal history of suicide attempt scanned with MRI

MRI

Intervention Type: OTHER

Structural and functional sequences

Healthy Controls

Healthy subjects over 60 years, not depressed and without personal history of severe mental illness or suicide attempts, scanned with MRI

MRI

Intervention Type: OTHER

Structural and functional sequences

Interventions

MRI

Structural and functional sequences

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• The patient must have given their free and informed consent and signed the consent form
• be a member or beneficiary of a health insurance plan
• aged 60 years-old or more
• must be right-handed
• with a diagnosis of a current major depressive episode of moderate to severe severity according to diagnostic criteria.
• with or without a personal history of attempted suicide during life
• hospitalized or followed by a consultant in the department of Psychiatry of Nîmes University Hospital or in the Sophoras private clinic

Exclusion Criteria

• The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study
• under safeguard of justice
• refuses to sign the consent
• It is impossible to give the subject informed information
• Current psychotic symptoms.
• Bipolar disorder.
• The subject presents an acute somatic decompensation incompatible with the realization of this study.
• The patient presents a mental confusion or a known Mini Mental State Examination score <24.
• Central neurological disease known in particular degenerative pathology, severe cranial trauma and severe cerebrovascular disease.
• Schizophrenia and other known psychotic disorders.
• Electroconvulsive therapy in the 12 months prior to study
• Inability to perform neuropsychological tests because of a language problem, poor understanding, a major tremor, inability to sit still, a major sight problem that cannot be corrected, or other severe cognitive impairment
• Contra-indication to magnetic resonance imaging (MRI): ferromagnetic implant in the body, piercing, claustrophobia, inability to remain elongated for 45 minutes.

• Minimum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier Universitaire de Nīmes

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Fabrice Jollant, MD PhD

Role: PRINCIPAL_INVESTIGATOR

CHU Nîmes

Locations

CHU Nimes

Nîmes, , France

Countries

France

Other Identifiers

LOCAL/2016/FJMW-01

Identifier Type: -

Identifier Source: org_study_id