Increasing the Oral Bioavailability of 6-prenylnaringenin by Micellar Solubilization
NCT ID: NCT03286777
Last Updated: 2018-10-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
6 participants
INTERVENTIONAL
2017-06-22
2018-07-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Placebo
Mannitol and silicon dioxide
Placebo
Mannitol and silicon dioxide capsules
Native 6-prenylnaringenin
250 mg native 6-PN plus mannitol and silicon dioxide
Native 6-prenylnaringenin
250 mg native 6-PN plus mannitol and silicon dioxide capsules
Micellar 6-prenylnaringenin
250 mg 6-PN in a micellar formulation with Tween-80 as adjuvant
Micellar 6-prenylnaringenin
250 mg 6-PN in a micellar formulation with Tween-80 as adjuvant capsules
Interventions
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Placebo
Mannitol and silicon dioxide capsules
Native 6-prenylnaringenin
250 mg native 6-PN plus mannitol and silicon dioxide capsules
Micellar 6-prenylnaringenin
250 mg 6-PN in a micellar formulation with Tween-80 as adjuvant capsules
Eligibility Criteria
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Inclusion Criteria
* Age: 18-45 years
* BMI: 19-25 kg/m2
Exclusion Criteria
* Alcohol and/or drug abuse
* Use of dietary supplements or any medications, except contraceptives
* Any known malignant, metabolic and endocrine diseases
* Previous cardiac infarction
* Dementia
* Participation in a clinical trial within the past 6 weeks prior to recruitment
* Physical activity of more than 5 h/wk
18 Years
45 Years
ALL
Yes
Sponsors
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Universität Tübingen
OTHER
University of Hohenheim
OTHER
Responsible Party
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Principal Investigators
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Jan Frank, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
University of Hohenheim
Sascha Venturelli, Dr. med. Dr. rer. nat.
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Eberhard Karls University Tuebingen, Germany
Christian Busch, Dr. med.
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Eberhard Karls University Tuebingen, Germany
Locations
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University of Hohenheim
Stuttgart, Baden-Wurttemberg, Germany
Eberhard Karls University Tuebingen
Tübingen, Baden-Wurttemberg, Germany
Countries
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Related Links
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Website of the research group
Other Identifiers
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HS-PF2-2017
Identifier Type: -
Identifier Source: org_study_id
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