Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2017-09-30
2018-10-30
Brief Summary
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Detailed Description
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Furthermore, it has been demonstrated that keeping a NIRS of 75-80% compared to the basal value reduces the risk of perioperative morbidity. On the other hand, a NIRS \< 50% of basal value seems to be predictive of an increase in morbidity.
All of those studies had been performed during CPB and knowledge lacks in management of DO2i and NIRS before and after CPB.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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NIRS
NIRS devices patch will be applied on patients' head in order to measure the cerebral saturation of each cerebral emisphere
DO2i
Oxygen delivery standardized to the body surface area will be calculate in order to optimize tissue perfusion
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Centro Cardiologico Monzino
OTHER
Responsible Party
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luca salvi
Anesthesia and ICU director
Principal Investigators
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Luca Salvi, MD
Role: PRINCIPAL_INVESTIGATOR
Centro Cardiologico Monzino
Central Contacts
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References
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Ranucci M, Romitti F, Isgro G, Cotza M, Brozzi S, Boncilli A, Ditta A. Oxygen delivery during cardiopulmonary bypass and acute renal failure after coronary operations. Ann Thorac Surg. 2005 Dec;80(6):2213-20. doi: 10.1016/j.athoracsur.2005.05.069.
de Somer F, Mulholland JW, Bryan MR, Aloisio T, Van Nooten GJ, Ranucci M. O2 delivery and CO2 production during cardiopulmonary bypass as determinants of acute kidney injury: time for a goal-directed perfusion management? Crit Care. 2011 Aug 10;15(4):R192. doi: 10.1186/cc10349.
Nielsen HB, Borglum J. Cerebral oxygenation in heart surgery. Anesth Analg. 2007 Aug;105(2):537; author reply 538-9. doi: 10.1213/01.ane.0000265698.02800.d4. No abstract available.
Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996 Jul;22(7):707-10. doi: 10.1007/BF01709751. No abstract available.
Other Identifiers
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R627/17-CCM 662
Identifier Type: -
Identifier Source: org_study_id
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