Pancreatic Exocrine Insufficiency After Bariatric Surgery

NCT ID: NCT03279653

Last Updated: 2017-09-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-01

Study Completion Date

2018-12-01

Brief Summary

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Main proposed benefit of sleeve gastrectomy is loss of ghrelin secreting tissue. Some studies express that ghrelin augment pancreatic regeneration. Therefore we hypothesized that with sleeve gastrectomy it may result with pancreatic insufficiency.

Detailed Description

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Mechanism of weight loss differs in bariatric surgery according to type of surgery.

With sleeve gastrectomy which has restrictive mechanism, ghrelin excretion decreases, and this condition is attributed as an additional mechanism in weight loss.

Ghrelin effects pancreatic regeneration, and loss of ghrelin may result with pancreatic insufficiency. Therefore we aimed to deteremine this association.

Conditions

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Obesity, Morbid Pancreatic Insufficiency

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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SleeveGastrectomy

Sleeve Gastrectomy will be performed. Preoperative and Postoperative pancreatic enzyme sufficiency (with steatocrit or fecal elastase) will be compared.

SleeveGastrectomy

Intervention Type PROCEDURE

Preoperative enzyme test before and after sleeve gastrectomy. Sleeve Gastrectomy will be performed. Preoperative (in one month) and Postoperative (after 3 months) pancreatic enzyme sufficiency (with steatocrit or fecal elastase) will be compared.

Interventions

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SleeveGastrectomy

Preoperative enzyme test before and after sleeve gastrectomy. Sleeve Gastrectomy will be performed. Preoperative (in one month) and Postoperative (after 3 months) pancreatic enzyme sufficiency (with steatocrit or fecal elastase) will be compared.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Patients underwent bariatric surgery (Sleeve gastrectomy) after concordonce with NIH criteria

Exclusion Criteria

Additional operations to sleeve gastrectomy like duodenal switch. Other bariatric operations.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Umraniye Education and Research Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Fatih Basak

M.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Fatih Basak, MD

Role: PRINCIPAL_INVESTIGATOR

University of Health Science, Umraniye Education and Research Hospital

Locations

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Umraniye Education and Research Hospital

Istanbul, Ümraniye, Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Fatih Basak, MD

Role: CONTACT

(+0216 6321818

Facility Contacts

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Fatih Basak

Role: primary

5055034571

Other Identifiers

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p-exocrine-insufficiency

Identifier Type: -

Identifier Source: org_study_id

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