Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
66 participants
OBSERVATIONAL
2019-09-01
2019-12-01
Brief Summary
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The aim of this study is to use new and advanced thermal imaging techniques to identify changes in the peripheral circulation and hand temperature in patients with liver disease. These changes could be used as a non-invasive marker of the severity and progression of liver disease. Thermal imaging will also be used to assess the changes in the peripheral vasculature with the use of terlipressin, a drug used as treatment for specific complications of liver disease.
Patients with acute or chronic liver disease from any aetiology will be recruited, along with patients without liver disease as healthy controls. Patients with disease or on drugs known to affect the peripheral vasculature will be excluded.
All studies will be performed in a ward setting in the Royal Infirmary of Edinburgh. The subjects will be required for up to three sessions, each lasting 30 minutes. The session will involve static thermal images being taken, and video images of the hands warming up after being cooled for 30 seconds in water at a temperature of 7 degrees Celsius. If the patient is receiving terlipressin therapy, static images will be taken before, during and after terlipressin therapy.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Liver disease
15 patients with acute or chronic liver disease of any aetiology. Serial static images to be taken at up to 3 time points using thermal imaging camera. Video images using thermal camera will be used to capture warming of one hand after cooling.
Patient may or may not be receiving terlipressin therapy.
Thermal imaging
Use of thermal imaging camera to capture images of peripheral vasculature (hands).
Normal
15 patients without liver disease, and without any other disease or drug known to affect the peripheral circulation.
Serial static images to be taken at up to 3 time points using thermal imaging camera. Video images using thermal camera will be used to capture warming of one hand after cooling.
Thermal imaging
Use of thermal imaging camera to capture images of peripheral vasculature (hands).
Interventions
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Thermal imaging
Use of thermal imaging camera to capture images of peripheral vasculature (hands).
Eligibility Criteria
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Inclusion Criteria
* diagnosis of acute liver disease (any aetiology)
Exclusion Criteria
* conditions known to affect peripheral circulation e.g. Raynauds
18 Years
70 Years
ALL
Yes
Sponsors
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University of Edinburgh
OTHER
Responsible Party
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Locations
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Univerity of Edinburgh and NHS Lothian
Edinburgh, , United Kingdom
Countries
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Other Identifiers
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IRAS ID 189169
Identifier Type: -
Identifier Source: org_study_id
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