The University of Hong Kong Neurocognitive Disorder Cohort
NCT ID: NCT03275363
Last Updated: 2017-09-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
500 participants
OBSERVATIONAL
2014-09-01
2022-01-04
Brief Summary
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Detailed Description
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Comprehensive profiling of each subject is performed through a multi-domain assessment protocol including detailed demographics, lifestyle factors, neuropsychological battery, mood, MRI, genetics, blood biomarkers, and other patient-centred parameters including level of disability, quality of life and societal engagement. Ongoing annual follow up captures the essential clinical events and changes in neurocognitive function (conversion to MCI or dementia), mood, level of disability and quality of life; as well as repeat blood tests.
The HKU NCD Cohort is the first-ever Asian dementia cohort to be formally included into the Dementia Platforms UK, achieving an international collaborative status with other UK-based cohorts. The study neuropsychological battery is aligned with the NACC UDS3 battery.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Cognitively normal controls (CNC)
No subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Neurocognitive battery
Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).
NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.
MRI
MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients
Blood tests
Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis
EEG with event-related potential (ERP)
128-channel EEG with ERP for Go/NoGo and Prospective Memory (PM) tasks for selected patients
Subjective cognitive decline (SCD)
Subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Neurocognitive battery
Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).
NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.
MRI
MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients
Blood tests
Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis
EEG with event-related potential (ERP)
128-channel EEG with ERP for Go/NoGo and Prospective Memory (PM) tasks for selected patients
Amyloid PET CT
F18 Flutametamol PET CT for selected patients
Mild cognitive impairment (MCI)
Subjective memory complaints Low HK-MoCA Normal instrumental ADL All interventions as described
Neurocognitive battery
Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).
NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.
MRI
MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients
Blood tests
Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis
EEG with event-related potential (ERP)
128-channel EEG with ERP for Go/NoGo and Prospective Memory (PM) tasks for selected patients
Amyloid PET CT
F18 Flutametamol PET CT for selected patients
Alzheimer's dementia
Subjective memory complaints Low HK-MoCA Poor instrumental ADL Probable Alzheimer's disease All interventions as described except EEG with ERP
Neurocognitive battery
Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).
NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.
MRI
MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients
Blood tests
Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis
Amyloid PET CT
F18 Flutametamol PET CT for selected patients
Vascular dementia
Subjective memory complaints Low HK-MoCA Poor instrumental ADL Related to stroke / cerebrovascular disease All interventions as described except EEG with ERP
Neurocognitive battery
Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).
NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.
MRI
MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients
Blood tests
Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis
Amyloid PET CT
F18 Flutametamol PET CT for selected patients
Interventions
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Neurocognitive battery
Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).
NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.
MRI
MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients
Blood tests
Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis
EEG with event-related potential (ERP)
128-channel EEG with ERP for Go/NoGo and Prospective Memory (PM) tasks for selected patients
Amyloid PET CT
F18 Flutametamol PET CT for selected patients
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
65 Years
ALL
Yes
Sponsors
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Dementias Platform UK
UNKNOWN
The University of Hong Kong
OTHER
Responsible Party
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Dr Joseph SK Kwan
Clinical Associate Professor
Principal Investigators
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Joseph SK Kwan, MD
Role: PRINCIPAL_INVESTIGATOR
The University of Hong Kong
Locations
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Department of Medicine, Queen Mary Hospital, The University of Hong Kong
Hong Kong, , Hong Kong
Countries
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Central Contacts
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Facility Contacts
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Related Links
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Profile of PI
Other Identifiers
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HKUNCDC
Identifier Type: -
Identifier Source: org_study_id
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