Study on the Effect of Online Cognitive Training Doses on Cognitive Function in Individuals With Mild Cognitive Decline
NCT ID: NCT07213362
Last Updated: 2025-10-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
234 participants
INTERVENTIONAL
2025-10-08
2026-12-31
Brief Summary
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To compare the differences in the efficacy of different doses of Computerized Cognitive Training (CCT) in improving cognitive function among patients with Mild Cognitive Impairment (MCI), and to explore the potential optimal intervention dose.
To analyze the interaction between individual characteristics and the intervention dose of CCT.
To compare the improvement in functional activity ability of MCI patients among different CCT intervention dose groups.
To compare the symptoms of depression and anxiety among different CCT intervention dose groups.
To evaluate the adherence to different doses of CCT intervention.
Participants will:
Receive CCT intervention at varying durations and frequencies over a 12-week period, and will be followed up for cognitive function, functional activity ability, etc., at weeks 4, 12, and 24.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Group 1: 30 min/session × 3 sessions/week
CCT Training, 30 minutes per session, 3 times a week, for a total of 12 weeks
Computerized Cognitive Training
Computerized Cognitive Training (30 minutes per session, 3 sessions per week, for a 12-week period)
Group 2: 45 min/session × 5 sessions/week
CCT Training, 45 minutes per session, 3 times a week, for a total of 12 weeks
Computerized Cognitive Training
Computerized Cognitive Training (45 minutes per session, 3 sessions per week, for a 12-week period)
Group 3: 60 min/session × 5 sessions/week
CCT Training, 60 minutes per session, 3 times a week, for a total of 12 weeks
Computerized Cognitive Training
Computerized Cognitive Training (60 minutes per session, 3 sessions per week, for a 12-week period)
Group 4: 30 min/session × 5 sessions/week
CCT Training, 30 minutes per session, 5 times a week, for a total of 12 weeks
Computerized Cognitive Training
Computerized Cognitive Training (30 minutes per session, 5 sessions per week, for a 12-week period)
Group 5: 45 min/session × 5 sessions/week
CCT Training, 45 minutes per session, 5 times a week, for a total of 12 weeks
Computerized Cognitive Training
Computerized Cognitive Training (45 minutes per session, 5 sessions per week, for a 12-week period)
Group 6: 60 min/session × 5 sessions/week
CCT Training, 60 minutes per session, 5 times a week, for a total of 12 weeks
Computerized Cognitive Training
Computerized Cognitive Training (60 minutes per session, 5 sessions per week, for a 12-week period)
Interventions
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Computerized Cognitive Training
Computerized Cognitive Training (30 minutes per session, 3 sessions per week, for a 12-week period)
Computerized Cognitive Training
Computerized Cognitive Training (45 minutes per session, 3 sessions per week, for a 12-week period)
Computerized Cognitive Training
Computerized Cognitive Training (60 minutes per session, 3 sessions per week, for a 12-week period)
Computerized Cognitive Training
Computerized Cognitive Training (30 minutes per session, 5 sessions per week, for a 12-week period)
Computerized Cognitive Training
Computerized Cognitive Training (45 minutes per session, 5 sessions per week, for a 12-week period)
Computerized Cognitive Training
Computerized Cognitive Training (60 minutes per session, 5 sessions per week, for a 12-week period)
Eligibility Criteria
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Inclusion Criteria
* Self-reported cognitive decline, confirmed by an informant.
* Montreal Cognitive Assessment (MoCA) score of 19-25, adjusted for years of education (+1 point for 12 years or less).
* Ability to complete activities of daily living independently.
* Possesses basic communication skills and is able to cooperate with the study procedures.
* Voluntarily agrees to participate in the study and signs the informed consent form.
Exclusion Criteria
* Presence of severe or unstable organic diseases such as cancer, hydrocephalus, history of central nervous system tumors, or acute brain injury/infection.
* Diagnosis of severe mental illness such as major depressive disorder, schizophrenia, schizoaffective disorder, or bipolar disorder.
* Presence of severe visual or hearing impairment, or other physical conditions that may interfere with the completion of the study.
* Participation in any other clinical trial within the past 3 months.
* Having received transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), light therapy, or having taken medications that could significantly affect cognitive function (e.g., nootropics, psychoactive drugs, anticholinergic drugs, benzodiazepines) for any reason within the past 6 months.
* History of alcohol dependence or substance abuse.
* Consumption of alcohol or other substances that affect cognitive function, such as caffeine or cocaine, within 24 hours prior to the cognitive assessment.
Any other conditions that the investigator deems unsuitable for participation in this study.
60 Years
ALL
No
Sponsors
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Peking University
OTHER
Responsible Party
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Haibo Wang
Research Fellow
Central Contacts
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Other Identifiers
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IRB00001052-25101
Identifier Type: -
Identifier Source: org_study_id
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