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Surgical Admission at the Weekend and 30-day Mortality in Ontario, Canada: a Matched Cohort Study

NCT ID: NCT03268044

Last Updated: 2018-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

340000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-10-18

Study Completion Date

2018-09-15

Brief Summary

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Surgery is performed at the weekend for risk to life or limb, when mandated by clinical guidelines, or depending on resource availability. Weekend healthcare interventions have been associated with increased mortality and adverse clinical outcomes in the majority of the literature examining the weekend effect, but these findings are not consistent. Results from recent observational studies argue against a true weekend effect. Higher rates of adverse outcomes associated with hospital activity at weekends do not appear to be due to altered medical staffing as commonly hypothesized, but are thought to be in part a result of data artefact and confounding by severity or indication. For this study, we hypothesized that patients who are admitted to hospital at the weekend and require surgery have an increased risk of death compared with patients who are admitted and undergo surgery on weekdays. The primary aim was to examine whether patients who underwent surgery and were admitted at the weekend had an increased risk of 30 day all-cause mortality compared with patients who were admitted and underwent surgery on weekdays; secondary aim was to examine whether the timing of surgery (i.e., surgery on the same weekend or surgery on a subsequent weekday) for patients admitted at the weekend is associated with increased risk of 30 day all-cause mortality.

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Detailed Description

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Conditions

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Surgery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Weekend admission

Adults admitted to hospital at the weekend (Saturday or Sunday) and who underwent surgery

Hospital admission and surgery

Intervention Type OTHER

Hospital admission and noncardiac surgery

Weekday admission

Adults admitted to hospital on a weekday (Tuesday to Thursday) and who underwent surgery

Hospital admission and surgery

Intervention Type OTHER

Hospital admission and noncardiac surgery

Interventions

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Hospital admission and surgery

Hospital admission and noncardiac surgery

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* any hospital admission associated with an eligible surgical procedure in the Ontario discharge abstract database
* between 2005 and 2015

Exclusion Criteria

* cardiothoracic or cardiology therapeutic procedures
* non-surgical therapeutic interventions (e.g. dialysis)
* obstetric procedures.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Hospital for Sick Children

OTHER

Sponsor Role lead

Responsible Party

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James O'Leary

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The Hospital for Sick Children

Toronto, Ontario, Canada

Site Status RECRUITING

Countries

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Canada

Facility Contacts

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James D O'Leary, MBBCh

Role: primary

[email protected]
4168131500 ext. 228845

Other Identifiers

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1000055744

Identifier Type: -

Identifier Source: org_study_id

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