Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
378 participants
OBSERVATIONAL
2017-07-20
2018-11-07
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Strata 0-0.05
Lowest probability of having familial hypercholesterolemia
Genetic testing
Targeted next-generation sequencing for familial hypercholesterolemia causative mutations
Strata 0.06-0.15
Second lowest probability of having familial hypercholesterolemia
Genetic testing
Targeted next-generation sequencing for familial hypercholesterolemia causative mutations
Strata 0.16-0.19
Moderate probability of having familial hypercholesterolemia
Genetic testing
Targeted next-generation sequencing for familial hypercholesterolemia causative mutations
Strata 0.20-0.34
Second highest probability of having familial hypercholesterolemia
Genetic testing
Targeted next-generation sequencing for familial hypercholesterolemia causative mutations
Strata greater than or equal to 35
Highest probability of having familial hypercholesterolemia
Genetic testing
Targeted next-generation sequencing for familial hypercholesterolemia causative mutations
Interventions
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Genetic testing
Targeted next-generation sequencing for familial hypercholesterolemia causative mutations
Eligibility Criteria
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Inclusion Criteria
* At least one cardiovascular co-morbidity or receiving treatment for a cardiovascular comorbidity
* Algorithm score 0-1
* Most recent encounter with a provider within five years of query date
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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The Familial Hypercholesterolemia Foundation
OTHER
Lancaster General Hospital
OTHER
University of Pennsylvania
OTHER
Responsible Party
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Locations
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Lancaster General Hospital
Lancaster, Pennsylvania, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Countries
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References
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Qureshi N, Da Silva MLR, Abdul-Hamid H, Weng SF, Kai J, Leonardi-Bee J. Strategies for screening for familial hypercholesterolaemia in primary care and other community settings. Cochrane Database Syst Rev. 2021 Oct 7;10(10):CD012985. doi: 10.1002/14651858.CD012985.pub2.
Other Identifiers
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826438
Identifier Type: -
Identifier Source: org_study_id
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