Safety and Immunogenicity of MSB11455 in Healthy Participants

NCT ID: NCT03251339

Last Updated: 2019-07-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

336 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-08-21

Study Completion Date

2018-09-22

Brief Summary

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The primary purpose of this study is to compare the immunogenicity and safety of MSB11455 and Neulasta in healthy adult participants.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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MSB11455

Participants received a single subcutaneous injection of MSB11455 6 milligram (mg) per (/) 0.6 milliliter (mL) on Day 1 in morning of treatment period 1 (28 Days) and 2 (28 Days). Period 1 and Period 2 are separated by a washout period of 35 Days.

Group Type EXPERIMENTAL

MSB11455

Intervention Type DRUG

Participants received a single subcutaneous injection of MSB11455 6 milligram (mg) per (/) 0.6 milliliter (mL) on Day 1 in morning of treatment period 1 (28 Days) and 2 (28 Days). Period 1 and Period 2 are separated by a washout period of 35 Days.

US-Neulasta

Participants received a single subcutaneous injection of US-Neulasta 6 mg/0.6 mL on Day 1 in morning of treatment period 1 and 2. Period 1 and Period 2 are separated by a washout period of 35 Days.

Group Type EXPERIMENTAL

US-Neulasta

Intervention Type DRUG

Participants received a single subcutaneous injection of US-Neulasta 6 mg/0.6 mL on Day 1 in morning of treatment period 1 and 2. Period 1 and Period 2 are separated by a washout period of 35 Days.

Interventions

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MSB11455

Participants received a single subcutaneous injection of MSB11455 6 milligram (mg) per (/) 0.6 milliliter (mL) on Day 1 in morning of treatment period 1 (28 Days) and 2 (28 Days). Period 1 and Period 2 are separated by a washout period of 35 Days.

Intervention Type DRUG

US-Neulasta

Participants received a single subcutaneous injection of US-Neulasta 6 mg/0.6 mL on Day 1 in morning of treatment period 1 and 2. Period 1 and Period 2 are separated by a washout period of 35 Days.

Intervention Type DRUG

Other Intervention Names

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pegfilgrastim

Eligibility Criteria

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Inclusion Criteria

* Participants who provide signed and dated written informed consent.
* Participants with laboratory test results within predefined ranges.

Exclusion Criteria

* Participants with known hypersensitivity to any component of US-Neulasta or MSB11455.
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Fresenius Kabi SwissBioSim GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Radmila Kanceva, MD, PhD

Role: STUDY_DIRECTOR

Fresenius Kabi SwissBioSim

Locations

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Auckland Clinical Studies Ltd

Auckland, , New Zealand

Site Status

Christchurch Clinical Studies Trust

Christchurch, , New Zealand

Site Status

Countries

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New Zealand

Other Identifiers

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EMR200621-003

Identifier Type: -

Identifier Source: org_study_id

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