OCP vs Metformin on Ovarian Stromal Blood Flow in PCOS

NCT ID: NCT03236740

Last Updated: 2018-03-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

101 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-08-01

Study Completion Date

2018-03-15

Brief Summary

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This study is undertaken to compare the effects of treatment with commonly used OCP containing ethinylestradiol-cyproterone acetate and metformin in women with PCOS. Special attention will be paid to changes in ovarian stromal blood flow by using Color Doppler and they will be correlated with changes in hormonal parameters post-treatment.

Detailed Description

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Conditions

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PCOS

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Metformin

Metformin 500mg bid in morning and evening after meals to be taken for 6 months.

Group Type ACTIVE_COMPARATOR

Metformin Hydrochloride

Intervention Type DRUG

Metformin Hydrochoride in the form of 500 mg tablets will be taken twice daily by participants.

OCP

OCP containing 35 microgram ethinylestradiol and 2-milligram cyproterone acetate to taken from the first day of the menstruation, oral administration of one pill daily for 21 days consecutively, then discontinue using the pill for seven days, and on the eighth day, restart taking the pill. OCP to be taken for 6 months.

Group Type ACTIVE_COMPARATOR

Ethinyl Estradiol-cyprosterone acetate

Intervention Type DRUG

Ethinyl Estradiol-cyprosterone acetate in the form of OCPs will be taken cyclically by the participants.

Interventions

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Ethinyl Estradiol-cyprosterone acetate

Ethinyl Estradiol-cyprosterone acetate in the form of OCPs will be taken cyclically by the participants.

Intervention Type DRUG

Metformin Hydrochloride

Metformin Hydrochoride in the form of 500 mg tablets will be taken twice daily by participants.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Women diagnosed with PCOS according to the Rotterdam criteria

Exclusion Criteria

* Current or previous use of oral contraceptives, glucocorticoids, antiandrogens, ovulation induction agents, antidiabetic and anti-obesity drugs or other hormonal drugs.
* Medical or surgical treatment of PCOS during the previous 3 months
* Presence of other endocrinopathies; except treated hypothyroidism on stable replacement doses of thyroid hormone
* Pregnancy, breastfeeding or desire for pregnancy during study interval (6 months)
* Inability to understand the proposal of the study precluding effective informed consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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S.C.B. Medical College and Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Priyadarshini Tripathy, MD

Role: PRINCIPAL_INVESTIGATOR

SCB Medical College

Locations

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SCB Medical College

Cuttack, Odisha, India

Site Status

Countries

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India

Other Identifiers

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OG/2017/12

Identifier Type: -

Identifier Source: org_study_id

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