Role of Macrophage Migration Inhibitory Factor (MIF) in Heart Failure

NCT ID: NCT03232671

Last Updated: 2022-11-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

180 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-31

Study Completion Date

2020-09-01

Brief Summary

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Evaluating the additional value of Macrophage Migration Inhibitory factor (MIF) in cardiovascular diseases when assessed in clinical routine.

Detailed Description

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Conditions

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Heart Diseases

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Interventions

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MIF ELISA

Blood sample

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

All patients presenting with symptoms of heart failure to the West-German Heart and Vascular Center according to the definition of the ESC 2016.

* Patients fulfilling criteria for the diagnosis of HFrEF
* Patients fulfilling criteria for the diagnosis of HFpEF
* Patients fulfilling criteria for the diagnosis of HFmrEF
* Patients presenting with dyspnea according to the NYHA classification I-IV, elevated BNP/NT-proBNP levels and echocardiographic findings of heart failure.

Exclusion Criteria

* Age \< 18 years
* Patients with symptoms of heart failure without fulfilling the criteria of the ESC guidelines 2016
* Denial to participate
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Essen

OTHER

Sponsor Role lead

Responsible Party

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Fadi Al-Rashid

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Peter Lüdike, M.D.

Role: PRINCIPAL_INVESTIGATOR

University Hospital of Essen, Department of Cardiology and Vascular medicine

Locations

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University Hospital of Essen

Essen, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

References

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Luedike P, Alatzides G, Papathanasiou M, Heisler M, Pohl J, Lehmann N, Rassaf T. Predictive potential of macrophage migration inhibitory factor (MIF) in patients with heart failure with preserved ejection fraction (HFpEF). Eur J Med Res. 2018 May 4;23(1):22. doi: 10.1186/s40001-018-0321-1.

Reference Type DERIVED
PMID: 29728137 (View on PubMed)

Other Identifiers

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15-6529-BO

Identifier Type: -

Identifier Source: org_study_id

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