SIBO & SIFO After Colectomy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-24

Study Completion Date

2016-02-26

Brief Summary

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After subtotal colectomy, 40% of patients report abdominal pain, gas and diarrhea, and poor quality of life; whose etiology is unknown. The investigators determined whether small intestinal bacterial (SIBO or fungal overgrowth SIFO) could cause these sympotoms (\> 1 year).

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Detailed Description

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Conditions

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Small Intestinal Bacterial Overgrowth Small Intestinal Fungal Overgrowth Colectomy

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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Colectomy Group

Mean age 52.3 years (range:20-85), 82% females, and a mean duration of symptoms of 79.9 months in the colectomy group. The indication for colectomy was constipation (36%), diverticular disease (8%), bowel obstruction (8%), colorectal carcinoma (8%), colon polyps (6%), and other (34%).

No interventions assigned to this group

Control Group

Mean age of 49.9 years (range 18-88), 76% females, and mean duration of symptoms 77.6 months,

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

patients who were referred to a specialist motility center over 4 year period with:

* Unexplained gastrointestinal symptoms such as gas, bloating, belching, diarrhea, and abdominal discomfort
* history of colectomy
* patients with no history of colectomy
* patients included who had normal: upper endoscopy, colonoscopy, computerized abdominal tomography scan, and normal hematology, biochemical profiles, tissue transglutaminase antibody, thyroid stimulating hormone, and normal right upper quadrant ultrasound scan.
* patients with glucose breath test and/or duodenal aspirate

Exclusion Criteria

* patients with upper gut or small bowel surgery
* Patients who were hospitalized or with serious cardiac or pulmonary or neurologic comorbidities
* Patients with intestinal strictures or known intestinal motility disorders such as scleroderma or pseudo-obstruction syndrome

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No