Seeing-Moving-Playing: Early Rehabilitation Utilizing Visual and Vestibular Technology Following Traumatic Brain Injury

NCT ID: NCT03215082

Last Updated: 2019-04-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-01

Study Completion Date

2020-12-31

Brief Summary

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The aim of this research program is to 1) Evaluate potential problems with vision, inner ear-eye reflexes and deficits of processing eye information that occur following TBI; and 2) Evaluate treatment programs for individuals with eye and inner ear problems that persist for greater than 10 days following injury.

This study will include 465 youth and young adults (aged 6-30 years old) who sustain a TBI of any severity. An initial evaluative phase using the best available technology to evaluate eye and inner ear function will be performed, and compared with typical tests that are used in the clinic. If symptoms and functional problems remain 10 days after injury, participants will be randomly placed into a treatment group (including eye movement, inner ear-eye reflex and attention exercises as per our pilot studies) or a control group (typical rehabilitation). Success will be measured in terms of return to sport (mild TBI), achievement of goals (moderate and severe TBI) and quality of life. It is expected that this program will inform clinical practice and future research leading to a treatment program in TBI that includes multiple components.

Detailed Description

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Conditions

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Mild Traumatic Brain Injury; Concussion

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Experimental

The intervention will be an individualized impairment-based program based on a pre-determined sequence. A minimal intervention for all participants randomized to the intervention group at all sites will include general oculomotor and gaze stabilization retraining as tolerated. Intervention activities will be recorded and described in detail in a treatment log.

Group Type EXPERIMENTAL

Vestibular-Visual Intervention

Intervention Type OTHER

vestibular-visual exercises

Control

Standard care for mild TBI consists mainly of general education, energy conservation, academic adaptations, and restricting children and adolescents from participation in vigorous physical activities as well as complex cognitive activities until complete symptom resolution. It is the usual approach promoted by various associations and consensus groups. In addition, in all participating centers, children and teens requiring musculoskeletal approaches to address neck pain/dysfunction will receive it as indicated, based on the clinical judgment of the local team. Participants with moderate and severe TBI will also receive rehabilitation activities as planned in their respective centers. The standard care intervention will be recorded and described in detail in a treatment log.

Group Type ACTIVE_COMPARATOR

standard care

Intervention Type BEHAVIORAL

standard care

Interventions

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Vestibular-Visual Intervention

vestibular-visual exercises

Intervention Type OTHER

standard care

standard care

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Mild TBI or moderate-severe TBI will be included

Exclusion Criteria

\-
Minimum Eligible Age

6 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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McGill University Health Centre/Research Institute of the McGill University Health Centre

OTHER

Sponsor Role lead

Responsible Party

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Isabelle Gagnon

Clinical Scientist

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary,

Calgary, Alberta, Canada

Site Status RECRUITING

Montreal Children's Hospital, MUHC

Montreal, Quebec, Canada

Site Status RECRUITING

Service de Rééducation des Pathologies Neurologiques de l'Enfant - Pôle de Rééducation et Réadaptation de l'Enfant Hôpitaux de Saint Maurice

Saint-Maurice, , France

Site Status RECRUITING

Department of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine

Tel Aviv, , Israel

Site Status RECRUITING

Countries

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Canada France Israel

Central Contacts

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Isabelle Gagnon, PhD

Role: CONTACT

514-412-4400 ext. 23896

Facility Contacts

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Kathryn Schneider, PhD

Role: primary

403-210-8951

Isabelle Gagnon, PhD

Role: primary

514-412-4400 ext. 23896

Mathilde Chevignard, PhD

Role: primary

01 43 96 63 40

Michal Katz-Leurer, PhD

Role: primary

97236405432

References

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Sorek G, Shaklai S, Gagnon I, Schneider K, Chevignard M, Stern N, Fadida Y, Kalderon L, Katz-Leurer M. Impact of Subarachnoid Hemorrhage on the Cardiac Autonomic Function During Rehabilitation in Children After Severe Traumatic Brain Injury. Neurotrauma Rep. 2023 Jul 14;4(1):458-462. doi: 10.1089/neur.2023.0032. eCollection 2023.

Reference Type DERIVED
PMID: 37475976 (View on PubMed)

Sorek G, Gagnon I, Schneider K, Chevignard M, Stern N, Fadida Y, Kalderon L, Shaklai S, Katz-Leurer M. The Cardiac Autonomic Response Recovery to the Modified Tilt Test in Children Post Moderate-Severe Traumatic Brain Injury. Brain Inj. 2022 Jul 3;36(8):1033-1038. doi: 10.1080/02699052.2022.2110942. Epub 2022 Aug 15.

Reference Type DERIVED
PMID: 35971307 (View on PubMed)

Sorek G, Gagnon I, Schneider K, Chevignard M, Stern N, Fadida Y, Kalderon L, Shaklai S, Katz-Leurer M. The integrated functions of the cardiac autonomic and vestibular/oculomotor systems in adolescents following severe traumatic brain injury and typically developing controls. Brain Inj. 2020 Sep 18;34(11):1480-1488. doi: 10.1080/02699052.2020.1807055. Epub 2020 Aug 18.

Reference Type DERIVED
PMID: 32809873 (View on PubMed)

Other Identifiers

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2018-3373

Identifier Type: -

Identifier Source: org_study_id

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