Epidural Analgesia vs Adductor Canal Block in Bilateral TKA
NCT ID: NCT03205540
Last Updated: 2021-05-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
70 participants
INTERVENTIONAL
2017-08-01
2021-05-01
Brief Summary
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Detailed Description
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Adductor canal block is less invasive than continuous epidural analgesia. It provides effective analgesia for total knee arthroplasty and preserves quadriceps muscle strength.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Epidural analgesia
Lumbar continuous epidural block
Continuous epidural block
Continuous epidural block at level L2-3 or L3-4 with 0.0625% bupivacaine + fentanyl 2 mcg/ml infusion epidurally 5 ml/hr for 48 hours postoperatively.
Bilateral ACB
Ultrasound-guided bilateral adductor canal blocks
Bilateral single-shot bilateral adductor canal blocks
Bilateral single-shot adductor canal blocks, ultrasound guidance, with 0.33% bupivacaine 15 ml on each side.
Interventions
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Continuous epidural block
Continuous epidural block at level L2-3 or L3-4 with 0.0625% bupivacaine + fentanyl 2 mcg/ml infusion epidurally 5 ml/hr for 48 hours postoperatively.
Bilateral single-shot bilateral adductor canal blocks
Bilateral single-shot adductor canal blocks, ultrasound guidance, with 0.33% bupivacaine 15 ml on each side.
Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists physical status classification 1-3
Exclusion Criteria
* Allergy to bupivacaine
* Weight less than 50 kilograms
* Hepatic disease
* Contraincation for neuraxial block or adductor canal block
* Uncontrolled cardiovascular disease
* Creatinine clearance less than 50 ml/min
18 Years
ALL
No
Sponsors
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Mahidol University
OTHER
Responsible Party
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Suwimon Tangwiwat
Assistant professor, Anesthesiology department, Faculty of Medicine Siriraj Hospital
Principal Investigators
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Suwimon Tangwiwat, MD
Role: PRINCIPAL_INVESTIGATOR
Siriraj Hospital
Locations
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Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok, , Thailand
Countries
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References
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Dimitris CN, Taylor BC, Mowbray JG, Steensen RN, Gaines ST. Perioperative morbidity and mortality of 2-team simultaneous bilateral total knee arthroplasty. Orthopedics. 2011 Dec 6;34(12):e841-6. doi: 10.3928/01477447-20111021-02.
Choi PT, Bhandari M, Scott J, Douketis J. Epidural analgesia for pain relief following hip or knee replacement. Cochrane Database Syst Rev. 2003;2003(3):CD003071. doi: 10.1002/14651858.CD003071.
Jenstrup MT, Jaeger P, Lund J, Fomsgaard JS, Bache S, Mathiesen O, Larsen TK, Dahl JB. Effects of adductor-canal-blockade on pain and ambulation after total knee arthroplasty: a randomized study. Acta Anaesthesiol Scand. 2012 Mar;56(3):357-64. doi: 10.1111/j.1399-6576.2011.02621.x. Epub 2012 Jan 4.
Gerrard AD, Brooks B, Asaad P, Hajibandeh S, Hajibandeh S. Meta-analysis of epidural analgesia versus peripheral nerve blockade after total knee joint replacement. Eur J Orthop Surg Traumatol. 2017 Jan;27(1):61-72. doi: 10.1007/s00590-016-1846-z. Epub 2016 Sep 3.
Fowler SJ, Symons J, Sabato S, Myles PS. Epidural analgesia compared with peripheral nerve blockade after major knee surgery: a systematic review and meta-analysis of randomized trials. Br J Anaesth. 2008 Feb;100(2):154-64. doi: 10.1093/bja/aem373.
Other Identifiers
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Si 245/2017
Identifier Type: -
Identifier Source: org_study_id
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