EUpertstrain 4 Study of Bordetella Pertussis Isolates

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

265 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-12

Study Completion Date

2016-12-31

Brief Summary

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This study focus on the genetic changes of B. pertussis clinical isolates. For this panels of B. pertussis isolates has been collected during four periods in different European countries.

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Detailed Description

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B. pertussis is considered as a monomorphic pathogen. However, genetic changes have been observed in several antigens (pertussis toxin, pertactin, filamentous haemagglutinin and fimbriae) included in the current acellular pertussis vaccines between vaccine strains and circulating isolates.

To study genetic changes in the B. pertussis populations in Europe, four distinct panels have been collected: EUpert I in 1999-2001 including 102 isolates, EUpert II in 2004-2005 including 154 isolates, EUpert III in 2007-2009 including 140 isolates and EUpert IV in 2012-2015 including 265 isolates. Selection criteria have remained unchanged for all four collections, which enables the opportunity to study changes in B. pertussis populations during the last 15 years.

Conditions

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Bordetella Pertussis, Whooping Cough

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Strain isolation from the nasopharynx

A group of culture positive whooping cough patients.

Strain isolation from the nasopharynx

Intervention Type OTHER

B. pertussis strains has been collected from the nasopharynx of the patients during the clinical visit

Interventions

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Strain isolation from the nasopharynx

B. pertussis strains has been collected from the nasopharynx of the patients during the clinical visit

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* B. pertussis clinical isolates should be collected from subjects from different regions and be epidemiologically unrelated.
* An equal number of isolates from vaccinated and unvaccinated subjects should be collected. Optimally, the isolates are preferred to be selected from individuals less than 5 years of age.
* For countries with large numbers of isolates in their collections, isolates should be randomly selected according to criteria above.

Eligible Sex

ALL

Accepts Healthy Volunteers

No